Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"BTG2"”.
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… inducible sequence 21), an ortholog of human BTG2 (B-cell translocation gene 2) and rat PC3, is a tumor suppressor that belongs to antiproliferative gene family, and is implicated in a variety of biological processes. Deregulation of c-Myc transcription factor is common in leukemia and …
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
BTG2(B-cell translocation gene2)is a member of the BTG/Tob family of anti-proliferative genes and has been implicated in various cellular processes including cell cycle progression, differentiation and apoptosis. Cellular senescence is an irreversible arrest of proliferation, which is induced by …
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TIS21 inhibits cell migration and invasion
TIS21/BTG2/PC3 is tumor suppressor gene and frequently downregulated in cancer tissue. In human tissue, decreased BTG2 is correlated with cancer cell metastasis, suggesting that suppression of BTG2 has a critical role in cancer cell migration and invasion. When we overexpressed TIS21 in A549 cells, …
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
TIS21/BTG2/PC3 (12-O-tetradecanoyl phorbol-13-acetate-inducible sequence 21) has been known as a p53 target gene and functions as a tumor suppressor in carcinogenesis of thymus, prostate, kidney, and liver. Although it has been known that the expression of TIS21/BTG2/PC3 was induced during …
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Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
… early genes (IEGs) including CYR61, COX2, BTG2, and ZFP36 were overexpressed in active GO and to a lesser degree in chronic GO, but not in chronic lymphedema. CYR61-responsive genes were also upregulated in active GO. In Study V, associations were found between SNPs in CYR61, BTG2, and …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… 3 (PC3) and human B-cell translocation gene 2 (BTG2). TIS21 regulates cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors. And In human tissue, BTG2 has a critical role in cancer cell …
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
… expression of B cell translocation gene 2 (Btg2), which encodes the anti-proliferative protein, BTG2. Overall, we demonstrate that ETV5 mutations can alter DNA binding activity and gene expression to promote a leukemic phenotype. These findings enhance our understanding of the role of ETV5 …
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
TIS21^(BTG2/PC3) regulates G1-S and G2-M progressions of cell division cycle through the inhibition of G1 phase cyclin biosynthesis, and the delayed degradations of cycin B1 and cyclin A, respectively. Therefore, we earlier suggested that TIS21 might play a role as a pan-cell cycle regulator and an …
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Regulation of Senescence Phenotypes by TIS21 gene in Huh7 Human Liver Cancer Cells
… TIS21(TPA inducible sequences 21), human에서는 BTG2(B-cell translocation gene-2), rat에서는 PC3(pheocromocytoma clone-3)로 존재하는 동등 유전자이다. TIS21는 세포내의 전사 보조 인자, 신경세포 분화인자 및 성장억제인자로서 thymocyte 의 stage-specific expansion 을 매개하는 중요인자이고 조혈모세포 증식억제인자로 보고된 바 있다. 이 외에도TIS21은 암 억제, 세포사멸(Apoptosis), cell …
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L'applicazione delle metodologie del nuovo approccio in vitro per chiarire i meccanismi di potenziale tossicità dell'EVP e delle sigarette combustibili
… è stata osservata una chiara induzione del Btg2-GFP associato a p53 e dei reporter del danno al DNA Rtkn dopo l'esposizione alla sigaretta. Questa induzione segnalata nel test ToxTracker dimostra la sua sensibilità verso i meccanismi correlati al danno al DNA e allo stress ossidativo. Al …