Global ETD Search
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Showing 1 to 13 of 13 for “"BTBI"”.
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Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular Function, Histopathological and Behavioral Outcomes in Rats
… (e.g. peroxynitrite, ONOO‾). Although blast TBI (bTBI) also reduces cerebral perfusion, less is known about other cerebral vascular effects of bTBI. To determine the effects of mild bTBI on cerebral vascular function with and without the administration of the ONOO‾ scavenger penicillamine methyl …
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High-Definition Fiber Tracking Study of the Executive Control Network in Blast-Related Traumatic Brain Injury
Blast-induced traumatic brain injury (bTBI) is common in Iraq and Afghanistan war veterans. However, subtle neural alterations and lack of a definitive biomarker impede clinical detection. The current study evaluated structure and functional correlates of executive control network (ECN) white …
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The Influence of Biomechanics on Acute Spatial and Temporal Pathophysiology Following Blast-Induced Traumatic Brain Injury
Blast-induced traumatic brain injury (bTBI) remains a significant problem among military populations. When an explosion occurs, a high magnitude positive pressure rapidly propagates away from the detonation source. Upon contact, biological tissues throughout the body undergo deformation at high …
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Mitochondrial Dynamics Alteration in Astrocytes Following Primary Blast-Induced Traumatic Brain Injury
Mild blast-induced traumatic brain injury (bTBI) is a modality of injury that has been of major concern considering a large number of military personnel exposed to the blast wave from explosives. bTBI results from the propagation of high-pressure static blast forces and their subsequent energy …
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Pressure versus impulse graph for blast-induced traumatic brain injury and correlation to observable blast injuries
… in combat, blast induced traumatic brain injury (bTBI) has become one of the signature wounds in current conflicts. Animal studies have been conducted to understand the mechanisms in the brain and a pressure versus time graph has been produced. However, the role of impulse in bTBIs has not been …
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Mechanics of blast-induced traumatic brain injury in porcine brain tissue
<p>Blast-induced traumatic brain injury (bTBI) often results from the detonation of improvised explosive devices (IEDs) in war settings. However, the material properties of the brain and their changes during and after bTBI are currently not well understood. Characterizing brain tissue is …
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Experimental and Finite Element Evaluation of Mild Traumatic Brain Injury
… tube, this study replicated blast-induced TBI (bTBI) in rats, examining the effects of single and multiple blast exposures on behavioral and histological outcomes. Behavioral evaluations using Rotarod and Open Field tasks, along with histological markers (GFAP, Iba-1, and tau protein), …
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Biomechanical Responses and Functional Outcomes in Large Animal and Human Surrogate Models of Primary Blast Injury
… led to a rise in blast traumatic brain injuries (bTBIs), particularly among military personnel. More than 515,000 servicemembers have been diagnosed with a traumatic brain injury (TBI) since the year 2000, and blast was reported to be the most common cause of TBI in modern U.S. military conflicts, …
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Transcranial Administration of Nano Pulse Laser Therapy for Blast Induced Neurotrauma
… a prophylactic treatment for a single blast TBI (bTBI) and through multiple applications as a therapeutic for repeated bTBI. In our first aim, male adult Sprague Dawley rats were treated with NPLT 24 hours prior to being subjected to blast TBI. Then the animals were assessed using Beam Balance, …
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Automated Rat Grimace Scale for the Assessment of Pain
… a RGS test for blast traumatic brain injury (bTBI). The validation dataset consisted of 40 control images of uninjured rats, 40 images from the bTBI study on the day of injury, and 40 images 1-month post-injury. All 120 images in the validation set were then manually graded for RGS and tested …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
… devices during combat has caused blast TBI (bTBI) to become a widespread consequence in military and Veteran populations, and impact-related trauma from contact-related sports or motor vehicle accidents has made mild impact-induced TBIs (concussion) a major health problem. There is a high …
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Experimental study of bubble rupture during shock-fluid interaction
… primary blast-induced traumatic brain injury (bTBI) is cavitation. It is hypothesized that cavitation can occur in the cerebrospinal fluid (CSF) layer, brain interstitial fluid, and possibly also in the cerebral blood. In this thesis, it is tested that if a bubble is present, it collapses when …
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Shock wave interaction with a fluid filled cylinder experimental methods
… of Iraq and Afghanistan, many soldiers sustained bTBI (blast-induced traumatic brain injury). The blasts are created by extensive use of improvised explosive devices (IED's). Whether pure blast-shock waves cause TBI or what is the mechanism of injury are not fully known. Research efforts are …