Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"BTB"”.
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Vaccinia virus BTB-Kelch proteins
… among which three, A55, C2 and F3, have a BTB/BACK-Kelch (BBK) structure and are the focus of this study. Proteins containing BTB and Kelch domains function as adapters for the cullin 3 (Cul3)-based E3 ubiquitylation system. VACV BBKs are not essential for viral replication, but they all …
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BTB-Kelch Proteins and TAk1 Kinase N Immune Function
BTB-kelch proteins are putative components of E3 ligases with a BTB domain at the N terminus and several kelch repeats at the C terminus. KLHL6 and mKELCH are two members of this family. Conditional ablation of Klhl6 in B cells resulted in mild developmental phenotypes in bone marrow precursors. …
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Insights into BTB-Cul3 Ubiquitin Ligases from the Structures of SPOP-Substrate Complexes
… In the largest CRL subfamily, Cul3 binds a BTB domain, and a protein-interaction domain such as MATH recruits substrates for ubiquitination. Here we present biochemical and structural analyses of the MATH and BTB domain containing protein, SPOP, which regulates diverse signaling pathways. …
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The burden and control of bovine tuberculosis in endemic settings
Bovine tuberculosis (bTB) is a major disease in cattle and also poses a public health risk due to transmission from animals to humans. The effectiveness of traditionally used strategies to control bTB, such as test-and-slaughter, varies considerably and the disease still persists in several places. …
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Questionnaire-based study to determine the state of tuberculosis testing in goats in South Africa
BACKGROUND In South Africa, bovine TB (bTB) is a state-controlled disease but the monitoring of bTB in small ruminants is largely neglected, whereas bTB diagnosis and surveillance in cattle and buffalo are prioritised due to limited resources. In communities where bTB surveillance is not conducted …
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Understanding the epidemiology of bovine TB and potential routes of infection by elucidation of fine-scale badger behaviour and movement
Bovine tuberculosis (bTB) is an endemic, zoonotic disease in cattle and badgers, which threatens animal health, farm productivity and commercial earnings within the U.K. and Ireland. Culling of badgers has been suggested as a potentially useful protocol to reduce the incidence of bTB in badgers and …
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Coregulatory Transcription Factors and Spermatogenesis
The BTB was hypothesized to be deficient in Etv5 -/- mice, and that this was mediated by Claudin 5 (CLD5). In both Etv5-/- and W/Wnu mice, the BTB was leaky. Examination of CLD5 expression among mice of various ages and phenotypes revealed the following: both ETV5 and germ cells were necessary for …
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Local Administration of Botulinum Toxin Type-B in the External Anal Sphincter of Horses Produces Transient Reduction of Peak Anal Pressure
… of this project was to determine the effects of BTB injection in the external anal sphincter in normal horses. Our hypothesis was that local injection of BTB would result in transient reduction of anal tone without causing clinical side effects. Peak and resting anal sphincter pressures of horses …
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Understanding animal movements to inform bovine tuberculosis surveillance: a framework for a targeted approach
Bovine tuberculosis (bTB) is a zoonotic disease that affects domestic and wildlife species. In recent years in the US, a novel scenario for bTB has arisen, characterized by sporadic outbreaks in cattle populations across the country and by spillover of the infection to wildlife. The cattle …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
The blood-testis barrier (BTB) protects developing germ cells by limiting entry of toxicants. This protective barrier poses a problem for therapeutic disposition to the male genital tract, which may allow viruses or cancer to persist in the testis, and impedes the development of male contraceptives …
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An investigation into the role of ubiquitination in plant immunity
… of AtPUB17 during plant defence. AtPOB1, a BTB/POZ-domain protein was isolated as an AtPUB17 interactor in a yeast-two-hybrid screen. The aim of this study was to confirm this interaction and to investigate the potential involvement of AtPOB1 in mediating disease resistance responses. The …
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Current source based wind energy conversion system
… pulse width modulated current source converter (BTB-PWM-CSC) as an interfacing converter for a variable-speed wind energy conversion system (WECS) that uses a permanent magnet synchronous generator (PMSG). It has been shown that the proposed current source converter based WECS can operate …
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Synthesis of cis- and trans-3-fluoroacrylate, and inhibition of BCL6 targeting a non-reactive cysteine
… project, a potential inhibitor that targets the BTB-domain of BCL6 was made in a multi-step route. The compound builds on preliminary data that shows a “switchable electrophile” strategy can be used to selectively and irreversibly modify a cysteine within the corepressor peptide binding site in …
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An investigation of the role of the Drosophila gene jim lovell in endopolyploid growth
… encodes a putative transcription factor of the BTB/POZ (Bric-a-Brac, Tramtrack, Broad/Pox virus and Zinc finger) domain class that is expressed in many elements of the developing larval nervous system. Lov has roles in innate behaviors such as larval locomotion and adult courtship. I have …
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Rodinný dům s podnikatelskou činností
… tvárnic POROTHERM a podzemní zdivo z tvárnic BTB. Stropní konstrukce keramická POROTHERM. Střecha sedlová.
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Underwater Direction-of-Arrival Finding: Maximum Likelihood Estimation and Performance Analysis
… At last, we derive a Barankin-type bound: BTB) on the mean-square error of DOA estimation using acoustic sensor arrays. The typical DOA estimation performance evaluation are usually based on the Cram'{e}r-Rao Bound: CRB), which cannot predict the threshold region of signal-to-noise ratio: …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… genes that encode proteins harboring a BTB/POZ-ZF domain in <em>Drosophila.</em> The BTB/POZ-ZF domain is associated with oncogenic activity in humans [11]. Towards meeting the aims of the Master’s Thesis research, we carried out: 1) loss-of-function (LOF) and gain-of-function (GOF) …
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Design and operation of Low Frequency AC (LFAC) transmission system for connecting offshore wind farms
… Back-to-Back Modular Multilevel Converter (BtB MMC) scheme for frequency conversion. Point-to-Point (PtP) and Multi-Terminal (MT) LFAC topologies are examined for various cable lengths to export the nominal capacity of the OWPPs or interconnect different OWFs and different grids through …
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AN INVESTIGATION OF THE MECHANISMS OF GROUCHO MEDIATED TRANSCRIPTIONAL REPRESSION
… Psq isoforms, containing and lacking the BTB domain. This analysis revealed a large overlap of Gro-bound regions with the binding sites of GAF and Nelf-E, which are two factors key in the establishment of the poised Pol II. A large overlap was also observed between Gro peaks and the …
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
… contacts of the Blood-testis barrier (BTB) displayed normal protein organization. Indeed, the BTB was intact by all accounts: by functional evaluations using biotin tracer injections, ultrastructural assessments using electron microscopy, and adhesion molecule localization using IF. In …
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