Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"BT-474"”.
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Developing Zebrafish as an In Vivo Model to Screen Compounds for Anti-Cancer Activity in Human Breast Cancer
… and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC cells were used to canvas the benign and malignant types of BC, respectively. Using fluorescently-labeled cells, the cytotoxic effect of doxorubicin, 4-hydroxytamoxifen, and paclitaxel were determined using a cell viability …
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Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment
… Ang-(1-7)-mediated reduction in tumor growth. BT-474, which express the ER receptor and over-express HER2, and ZR-75-1 ER positive cells were injected into a mammary fat pad of athymic mice. Tumors were allowed to grow to a uniform size, 200 mm3 and 100 mm3 for BT-474 and ZR-75-1, respectively, …
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Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells
… of ERalpha-positive and HER2-positive BT-474 and ERalpha-positive and HER2-negative MCF-7 breast cancer cell lines. LRIG1 regulation by estradiol may be important for breast cancer etiology and phenotypic properties by influencing signaling pathways such as the AKT and MAPK pathways, …
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Computational modeling of tumor cell growth as a function of nutrient dynamics guided by time-resolved microscopy
… and validated in two breast cancer cell lines (BT-474 and MDA-MB-231) and demonstrated accuracy in predicting tumor growth. Secondly, we developed noninvasive imaging of nutrient dynamics with a stable transfection of two FRET reporters, one assaying glucose concentration and one assaying …
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The role of actin isoforms in cancer adhesion of the endothelium during metastasis
… cancer models; healthy (hTERT-HME1), primary (BT-474) and metastatic (MCF7) breast epithelial tissue were tested for the presence of cell and EV surface γ-actin using immunocytofluorescence and flow cytometry. Once the EVs were characterised, different variations of cell line EVs and cells were …
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NF1 AS A REGULATOR OF CYTOSKELETON DYNAMICS AND BIOMARKER FOR DECISION-MAKING IN HER2-POSITIVE BREAST CANCER
… NF1 knockout (KO) HER2+ BC cells (i.e.: BT-474, SK-BR-3, HCC1954) by CRISPR/Cas9. NF1KO cells demonstrated exquisite sensitivity to the antibody-drug conjugate (ADC) trastuzumab emtansine (T-DM1). This hypersensitivity was specific to the mertansine MT-targeting component (DM1) since it …
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A Microfluidic Tissue Array (µFTA) For Personalized Medicine using Tumor Biopsies
… xenografts (CDX, e.g. MB-MDA-231 and BT 474) and patient-derived xenografts (PDX, e.g. M37 and M156) breast cancer models. As this work was in progress, other labs have also worked on creating a whole tissue culture system, but employ very low-throughput systems or systems that do not …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… P-Rex1 protein levels in breast cancer MCF-7 and BT-474 cells with a maximum reduction of 87.2 ± 1.1 and 57.0 ± 8.6%, respectively, at a concentration of 10 ng/ml. Interestingly, either silence of P-Rex1 by siRNA or PMA treatment inhibits breast cancer cell proliferation by over 70%, which can be …
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Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… invasiveness of ERα-positive and HER2-positive BT-474 and ERα-positive and HER2-negative MCF-7 breast cancer cell lines. LRIG1 regulation by estradiol may be important for breast cancer etiology and phenotypic properties by influencing signaling pathways such as the AKT and MAPK pathways, which …
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… in mice bearing subcutaneous HER2-expressing BT-474 human breast cancer xenografts. The<em> in vivo</em> performance of [<sup>177</sup>Lu]Lu-CHX-A′′-DTPA<sub>PODS</sub>-<sup>HER2</sup>DVD matched that of <sup>177</sup>Lu-labeled trastuzumab, with the former producing a tumoral activity …