Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"BSEP"”.
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Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
… importance of the liver bile salt export pump (BSEP) and the need to test for BSEP inhibition at an early stage of drug development. An assay for BSEP-mediated bile acid transport was established to study the biochemical mechanisms of inhibition of BSEP activity by organic compounds. The four …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… canalicular transporters bile salt export pump (Bsep) und multidrug resistance protein 2 (Mrp2) were analyzed after 0.5, 1,3 and 5 days of ethinylestradiol treatment (5mg/kg) in rats. Regulation in mRNA and Protein levels were determined by northern and westernblotting. Binding activities of …
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Genetische Prädisposition der intrahepatischen Schwangerschaftscholestase : Mutationsanalyse des Phospholipidtransporters ABCB4 und der Gallensäurenexportpumpe ABCB11
… in the ABCB11 encoding the bile salt export pump BSEP may as well predispose for ICP. In 28 Swedish and German patients suffering from MSUD a mutational analysis was accomplished, furthermore clinical and biochemical data were obtained and correlations were calculated. There was a clear …
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High-throughput approaches to sourcing of human hepatocytes for cell-based therapies
… adult markers such as CYP3A4, CYP2A6, PXR and BSEP, concomitant with downregulation of persistent fetal marker AFP. In the final section of this thesis, we explore the therapeutic potential of identified small molecules in vivo. Using zebrafish models from the Goessling/North lab, we observed …
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Role of Src phosphorylation of FXR in bile acid regulation
… regulation, particularly bile salt export pump (BSEP) and SHP. Disruption of this site in vivo also led to elevated bile acid levels, elevated liver enzyme levels, and increased macrophage infiltration; all signs of liver damage. Additionally, when challenged in models simulating cholestasis, …