Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"BRIN-BD11"”.
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Transglutaminase in the life and death of the pancreatic β-cell
… models of rat pancreatic insulinoma β-cells (BRIN-BD11), and ex vivo islet of Langerhans models from human, rat, TG2(-/-) knockout mice and their wild-type counterparts. The importance of ECM-associated TG2 in the maintenance of β-cell survival and function was also investigated using an in …
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Investigation of insulinotropic and cytoprotective effects of selected amphibian skin peptides
… oxidative stress in clonal pancreatic cells, BRIN-BD11, and microglial cells, BV2. The purity of commercially synthesised selected peptides was confirmed using reversed-phase HPLC. Insulin-releasing effects of graded concentrations of selected peptide (0 - 3μM) were studied in a 20 min acute …
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Biopolymers for Bioartificial Pancreas
… of 15% w/v was the best scaffold for the BRIN BD11cells. Next, the polymers were fabricated into 2D & 3D structures and evaluated for function. No statistical difference was observed when the mechanical properties of both 2D & 3D structures were compared. The same trend was observed for …
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The effects of the adipocyte-secreted proteins resistin and visfatin on the pancreatic beta-cell
… to do this, pancreatic β-cell lines from rat (BRIN-BD11) and mouse (βTC-6) were used to study the effect of exogenous incubation with physiological and pathological concentrations of resistin and visfatin on diverse elements of beta-cell biology including cell viability, gene expression and …
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Investigation of insulin releasing and glucose lowering effects of extract of selected plants used in African traditional medicinal practice
… the highest insulin-releasing effects on BRIN-BD11 cells (7.2-fold at 1000 μg/ml, P<0.001). The investigation of mechanisms underlying the insulin-releasing effects of these extracts revealed that the ATP-dependent pathway is likely involved in the actions of these extracts. All tested …
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Biological activities and antidiabetic potential of novel peptides from frog secretions
… a dose-dependent insulinotropic activity in BRIN-BD11 cells, which is regulated by ATP-sensitive potassium channel depolarisation triggered extracellular calcium influx and GLP-1 receptor-initiated PKA signalling activation. In Chapter 4, the novel Dermaseptin-PS1 was demonstrated to possess …
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Relationship of the glycation gap to diabetes and its complications, and the potential role of adipokines
… assessment of insulin secretion from MIN6 and BRIN-BD11 cells, effects of WISP1 on beta cells viability, effects of some adipokines (WISP1, eNAMPT/Visfatin, sFRP4) on insulin secretions/release from pancreatic beta cell. To this end, MIN6 cells were cultured in low and high glucose media, …
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In-vivo and in-vitro study of mechanism of action of 4 hydroxyisoleucine as an amino acid derived from fenugreek seed with anti-diabetic and properties
… molecular backbone as 4-hydroxyisoleucine. BRIN-BD 11, a functional and glucose responsive pancreatic beta cell, was selected as a cell model which is not insulin-responsive and dependent on the insulin signalling pathway for glucose uptake. Use of the model provides the opportunity to study …