Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"BRG1"”.
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SMARCA4/BRG1-Inactivating Mutations as Potential Predictive Markers for Aurora Kinase A-Targeted Therapy in NSCLCs
… of the SWI/SNF chromatin remodeling complex, BRG1. Frequent occurrence of SMARCA4/BRG1-inactivating mutations and their mutually exclusive nature from EGFR and ALK lesions create one of the largest subsets of Non-Small Cell Lung Cancers (NSCLCs). Since these mutations have been identified as …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
… <p>Additionally, we demonstrate that BRG1, the catalytic component of the chromatin remodeling complex SWI/SNF, plays a critical role in the maintenance of the GICs and in the drug resistance of these cells. We show that BRG1 promotes the expression of key stem cell markers, Oct4, …
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… chromatin remodelling complexes contain either BRG1 or BRM as the core ATPase together with other common and variable subunits. BRG1 is required for terminal epidermal differentiation in mice and humans and for hair follicle stem cell activation during mouse hair follicle regeneration and …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… its interaction with Brahma-related gene-1 (BRG1, encoded by the SMARCA4 gene, the catalytic subunit of the hSWI/SNF chromatin remodelling complex). I have demonstrated that an NPM1-ALK-BRG1 axis exists whereby loss of NPM1-ALK catalytic activity results in the proteasomal degradation of …
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Role of PBRM1 in regulation of the HIF pathway
… regulate the expression of HIF1α in a BRG1-independent manner. PBRM1 is important for recognition of HIF1α mRNA by YTHDF2 and able to interact with mRNA suggesting a link between this chromatin remodeling complex and mRNA processing. Additionally, PBRM1 contributes to the hypoxia …
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Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… with the nucleosome remodeling complex subunit Brg1 and with the histone acetyltransferase GCN5. These observations provide the first direct evidence for HSI POU1F1-mediated cofactor recruitment in the distal activation of hGH-N by a chromatin-modification mechanism. Finally, an inducible …
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THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
… We determined that the SWI/SNF family members BRG1, ARID1A and BAF155 may participate in the complex that activates GABPbeta transcription in conjunction with NRF-1. Examination of NRF-1, GABP and BRCA1 in 3D culture models suggests that mammary epithelial differentiation is biphasic with the …
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Serum response factor-dependent regulation of smooth muscle gene transcription
… muscle cells I showed how SRF acts together with Brg1-containing chromatin remodeling complexes to regulate expression of microRNAs-143, 145, 133a and 133b. Moreover, I found that SRF transcription cofactor myocardin acts together with SRF to regulate expression of microRNAs-143 and 145 but not …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… and chromatin remodelling factors (Satb1, Brg1), but also polycomb proteins and components of the nuclear envelope, suggesting the existence of a functional link between cytoskeleton, nuclear architecture and three dimensional nuclear organization. Other proteins important for proper …