Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"BRD3"”.
-
Molecular regulation of BRD3 in forward programming of Megakaryocytes
… association studies (GWAS) have identified BRD3 as a regulator of platelet traits. BRD3, along with BRD2, BRD4 and BRDT, is classified within the bromodomain and extra terminal (BET) family, specialised in recognising and binding to acetylated lysine residues. In this project, I studied the …
-
The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… Conversely, these tumours transitioned to a BRD3-driven state, which was recruited to newly accessible genomic regions. This recruitment promoted transcription elongation by mediating the phosphorylation of Ser2 on the RNA polymerase II C-terminal domain. Using a cutting-edge PROTAC approach …
-
The role of BET proteins in castration-resistant prostate cancer dissemination
… the Bromodomain and ExtraTerminal (BET – BRD2, BRD3 and BRD4) family of proteins, to test the hypothesis that each BET family member regulates EMT and underlying characteristics such as cell motility and invasiveness. We systematically manipulated the BET proteins and found that BRD4 regulates …