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Showing 1 to 20 of 81 for “"BRCA2"”.

  1. FANCD2 in relation to BRCA2 mutated breast cancer

    Snædís Ragnarsdóttir 1989-2019

    … and caused by mutations in the BRCA1 and BRCA2 genes. BRCA1 and BRCA2 proteins have been shown to be involved in a multitude of pivotal cellular processes and are required for maintenance of chromosomal stability including DNA homologous recombination (HR) repair and DNA replication …

    u-iceland Repository record

  2. Transcriptional and Chromatin Disorientation Associated with BRCA2 Inactivation

    Gupta, KomalUniversity of Cambridge2023

    … germline mutations in the tumour suppressor gene BRCA2 predispose to breast, ovarian, prostate and pancreatic cancer. Functionally, BRCA2 protein is involved in genome integrity maintenance via homologous recombination repair, DNA replication fork protection, and R-loop resolution. However, the …

    cambridge Repository record

  3. Risk Perception Among BRCA1 and BRCA2 Mutation Negative Patients

    Johnson, Kelsey

    … cancer risk. Testing negative for BRCA1 and BRCA2 mutations does not completely eliminate the heritable component of cancer, nor does it eliminate the risk to relatives of affected women. This increased risk may be difficult for patients to comprehend and explain to family members. By …

    south-carolina Repository record

  4. Mechanisms of human RAD51 regulation by RAD52 and BRCA2

    Constantinou, StephanieUniversity of Cambridge2019

    … in eukaryotic organisms – the tumour suppressor, BRCA2, and RAD52. Recent evidence suggests that human RAD52 becomes essential for viability in cancer cells lacking BRCA2, making its activity an attractive target for potential therapeutic strategies. However, the mechanisms by which RAD52 and …

    cambridge Repository record

  5. Mechanisms underlying genome maintenance and tumour suppression by BRCA2

    Chadha, SaakshiUniversity of Cambridge2019

    … of germline pathogenic mutations in a single BRCA2 allele predisposes carriers to cancers of the breast, ovaries, pancreas, prostate and other tissues. BRCA2 encodes a complex protein of 3418 residues, with multiple distinct regions implicated in different cellular processes including …

    cambridge Repository record

  6. INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION

    PAPAGUDI VENKATRAM, RAJAGOPALUniversità degli Studi di Milano2025

    … involves homologous recombination (HR) proteins BRCA2 which protects DNA replication intermediates from nuclease-mediated degradation. Emerging evidence demonstrates that HR proteins like BRCA2 co-evolved with the cytosine methylation machinery, suggesting a functional link between the two …

    milano Repository record

  7. Reproductive and somatic functions of RAD51A and BRCA2 genes in maize

    Milsted, Claire2021

    RAD51 and BRCA2 are conserved proteins involved in homology-directed DNA double-strand break (DSB) repair. This form of DSB repair occurs in somatic cells and is also the essence of meiotic recombination, which allows gametes to have different combinations of alleles and facilitates proper division …

    umn Repository record

  8. Deciphering the role of BRCA2 at the damage-induced G2 checkpoint

    Ahmad, Syed SaifUniversity of Cambridge2018

    … The large 3418 residue protein encoded by BRCA2 – heterozygous germline mutations in which predispose to cancer - has recently been implicated in G2 checkpoint maintenance. However, the mechanistic basis of BRCA2’s role in the G2 checkpoint remains unknown. The overall aim of my research is …

    cambridge Repository record

  9. Áhrif sértæks Aurora-A kínasahindra á brjóstaþekjufrumulínur með stökkbreytingu í BRCA2 geninu

    Stefanía Lind Stefánsdóttir 1984-2011

    … Einn af þessum erfðagöllum er stökkbreyting í BRCA2 geninu, en hún erfist með Mendelskum erfðum og finnst í 7-8% brjóstakrabbameinstilfella á Íslandi. Það sem einkennir þær konur sem eru arfblendnar með þessa stökkbreytingu er að þær þróa með sér krabbameinið fyrr en þær sem hafa ekki …

    u-iceland Repository record

  10. Aurora A nuclear expression and telomere length in BRCA2 related breast cancer

    Margrét Aradóttir 1987-2013

    … vestræna heimi. Arfgengar stökkbreytingar í BRCA2 geninu tengjast aukinni brjóstakrabbameinsáhættu og arfberar eru almennt að greinast yngri. Í þessari rannsókn voru skoðuð annars vegar Aurora A yfirtjáning í brjóstaæxlissýnum og hins vegar telomere lengd í blóðsýnum frá …

    u-iceland Repository record

  11. Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian

    Mersch, Jacqueline2014

    <p>Mutations in <em>BRCA1</em> and <em>BRCA2</em> cause tumor development in Hereditary Breast and Ovarian Cancer syndrome (HBOC) through accumulation of unrepaired DNA damage. Extensive research of <em>BRCA1</em> and <em>BRCA2</em> mutations has led to well-defined breast and ovarian cancer risks …

    uthsc Repository record

  12. The Molecular Mechanisms of BRCA2 in Tumourigenesis: A Novel Aldehyde/Proteasome Axis

    Parande, RheaUniversity of Cambridge2022

    [Restricted]

    cambridge

  13. Factors Influencing Uptake of Risk-Reducing Salpingo-Oophorectomy By Brca1 and Brca2 Mutation Carriers

    Breen, Victoria E2017

    … mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes are associated with significantly increased risks for ovarian cancer. The National Comprehensive Cancer Network (NCCN) currently recommends that female BRCA mutation carriers undergo risk-reducing salpingo-oophorectomy (RRSO) after …

    uthsc Repository record

  14. Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers

    Streff, Haley2016

    <p>Mutations in the <em>BRCA1</em> or <em>BRCA2</em> genes are associated with increased risks for breast, ovarian, and several other cancers. The purpose of this study was to evaluate the incidence of cancers in first and second degree relatives of <em>BRCA</em> mutation carriers compared to the …

    uthsc Repository record

  15. Vulnerability to G - Quadruplexes in BRCA2 - Null Medulloblastoma: A Protective Role for the PIF1 Helicase

    Keahi, Danielle L2025

    … mutations in the essential DNA repair factor BRCA2 are highly predisposed to develop the most common pediatric brain cancer medulloblastoma (MB) before three years of age. Medulloblastoma is often the first malignancy in these children who have a high likelihood of developing several other …

    rockefeller Repository record

  16. UNRAVELING THE MOLECULAR MECHANISM OF BRCA2-POLTETA INTERPLAY IN PREVENTING SSDNA GAP ACCUMULATION DURING DNA REPLICATION

    RAMIREZ OTERO, MIGUEL ANGELUniversità degli Studi di Milano2023

    … of POLθ beyond alt-NHEJ and its interplay with BRCA2 during DNA replication. We find that BRCA2-deficient cells accumulate replication-associated single-stranded DNA (ssDNA) gaps, which lead us to explore the role of POLθ in repairing these gaps. By employing a novel POLθ polymerase inhibitor …

    milano Repository record

  17. Family Environment, Social Support, and Psychological Distress of Women Seeking BRCA1 and BRCA2 Genetic Mutation Testing

    Keenan, Lisa A.University of North Texas2002

    … on women seeking genetic testing for BRCA1 and BRCA2 gene mutations. This study further explored patterns of psychological distress for 51 community women waiting to receive such genetic test results. There was no significant relationship between psychological distress and family cancer history, …

    unt Repository record

  18. The molecular pathology of BRCA1 and BRCA2 in breast cancer patients from the West of Scotland

    Ghaffari, GuityUniversity of Glasgow1997

    Abstract available p. i-iii

    glasgow Repository record

  19. Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants

    Rogers, Rosemary, <p>https://orcid.org/0000-0002-1799-238X</p>2022

    … suggests that germline <em>BRCA1</em> and <em>BRCA2</em> pathogenic and likely pathogenic (P/LP) variants may increase susceptibility to t-MNs due to the genes’ established role in DNA damage response. There is also evidence that individuals with <em>BRCA1/2</em> P/LP variants may be more …

    uthsc Repository record

  20. Factors Associated With Early Versus Late Development of Breast and Ovarian Cancer In Brca1 and Brca2 Positive Women

    Cooper, Justine M2010

    … (HBOC) is caused by a mutation in the BRCA1 or BRCA2 genes. Women with a BRCA1/2 mutation are at increased risks for breast and ovarian cancer and often develop cancer at an earlier age than the general population. However, some women with a BRCA1/2 mutation do not develop breast or ovarian …

    uthsc Repository record

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