Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"BRCA1 deficiency"”.
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Initiating mutations and chemoprevention in BRCA1 mutation carriers
BRCA1 mutation carriers have a significant lifetime risk of developing breast cancer. Currently, these women are offered risk-reducing bilateral mastectomies, which have significant physical risks and psychosexual implications, or chemoprevention strategies that have little evidence to support …
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53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis
… the efficacy of PARP1 inhibitors (PARPi) in BRCA1-deficient cancers. Additionally, 53BP1 promotes end-to-end fusions of telomeres lacking end protection from the shelterin component TRF2, and facilitates end-joining at programmed breaks generated during class switch recombination in the …