Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"BRCA mutation"”.
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Assessing risk of familial breast cancer: effectiveness of current UK guidelines
… (3-8%) and high risk (>8%). Those with a BRCA mutation are considered to be very high risk. Women at moderate or high risk are offered screening from age 40. This study aimed to assess the effectiveness of NICE risk categorisation at identifying women at risk of early onset breast …
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Factors Influencing Uptake of Risk-Reducing Salpingo-Oophorectomy By Brca1 and Brca2 Mutation Carriers
<p>Germline mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes are associated with significantly increased risks for ovarian cancer. The National Comprehensive Cancer Network (NCCN) currently recommends that female BRCA mutation carriers undergo risk-reducing salpingo-oophorectomy (RRSO) …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… (PARPi) emerge as potential targeting drugs for BRCA-deficient cancers including triple negative breast cancer (TNBC). However, it has been reported that a subgroup of patients even with BRCA mutation fails to respond to PARPi in multiple clinical trials. In this study, we identified c-Met, a …
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Natural Law, the Object of the Act, and Double Effect: Moral Methodology for Catholic Health Care Ethics
… to justify bilateral salpingo-oophorectomies for BRCA mutation carriers and the uses of contraception for victims of sexual assault. Chapter 6 discusses the use of sex reassignment therapies for gender dysphoria and the use of contraceptive methods for non-contraceptive benefits.</p>
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Krūties vėžio magnetinio rezonanso vaizdo tekstūros analizė /
… in the detection of breast cancer linked to BRCA1 and BRCA2 gene mutations and to identify precise radiomic features that could develop new non-invasive breast cancer diagnostic approaches, oriented at genetics. Methods: A prospective analysis of MRI radiomic features and genetic data from 42 …
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Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
… An increasing body of evidence suggests BRCA1, a tumor suppressor gene with a variety of functions including DNA repair and cell cycle regulation, plays a role in telomere maintenance. Mutations in BRCA1 account for approximately half of all hereditary breast and ovarian cancers, and the …
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Factors Associated With Early Versus Late Development of Breast and Ovarian Cancer In Brca1 and Brca2 Positive Women
… breast and ovarian cancer (HBOC) is caused by a mutation in the BRCA1 or BRCA2 genes. Women with a BRCA1/2 mutation are at increased risks for breast and ovarian cancer and often develop cancer at an earlier age than the general population. However, some women with a BRCA1/2 mutation do not …
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Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian
<p>Mutations in <em>BRCA1</em> and <em>BRCA2</em> cause tumor development in Hereditary Breast and Ovarian Cancer syndrome (HBOC) through accumulation of unrepaired DNA damage. Extensive research of <em>BRCA1</em> and <em>BRCA2</em> mutations has led to well-defined breast and ovarian cancer risks …