Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"BRCA genes"”.
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Blame it on her genes : on performativity, politics, and the consumption of prevention
… breast and ovarian cancer, and a specific set of genes, the BRCA genes, which are associated with an increased risk of developing the disease over a lifetime. By integrating concepts developed within the sociology of health and illness with those that are informing the area of market studies, this …
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The effect of distinct BRCA1 splice forms on drug sensitivity in breast- and ovarian cancer cell lines
Germline mutations in BRCA-genes cause higher risk of cancer development, particularly in breast and ovaries. PARP inhibitors are a promising treatment option for carriers of BRCA1/2 mutations diagnosed with these tumor types. Pathogenic spliceogenic variants have been found in BRCA1 that change …
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Analysis of The RING Domain And BRCT Repeats of BRCA1
Mutations within BRCA1 often contribute to breast cancer susceptibility. Many of these mutations cluster within two highly conserved regions that may be important for BRCA1's functions: the RING domain and the BRCT repeats. BRCA1's RING domain has E3 ubiquitin ligase activity, which is greatly …