"BRAFi" · 2 results · Global ETD Search

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Showing 1 to 2 of 2 for “"BRAFi"”.

Investigation of signalling pathways associated with the development of BRAF inhibitor resistance and treatment of melanoma

Boz Er, Asiye B.University of Bradford2025

… of integrins during the development of BRAFi resistance. To understand which RGD binding integrins and mechanisms are involved in BRAFi resistance in melanoma cells, in this study, BRAFV600E mutant vemu-rafenib resistant cell lines were generated and gene expression analysis (2-ΔΔCt) for …

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An investigation on role of the ATP-binding cassette B5 (ABCB5) transporter as potential mediator of melanoma resistance to BRAF inhibition

Tangella, Lokeswari PrathyushaEdith Cowan University, Research Online, Perth, Western Australia2020

… therapies, in the form of BRAF inhibitors (BRAFis), have been effective at treating BRAFV600 mutant melanomas. However, majority of the melanoma patients fail to respond to BRAFis due to intrinsic or acquired resistance within one year of treatment commencement. Multiple mechanisms that …

edithcowan Repository record for An investigation on role of the ATP-binding cassette B5 (ABCB5) transporter as potential mediator of melanoma resistance to BRAF inhibition (opens in a new tab)