Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"BRAF mutation"”.
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A Phase I Dose-Escalation Study of The Braf Inhibitor Vemurafenib In Combination With The Mtor Inhibitor Everolimus In Subjects With Advanced Cancer
… for the treatment of relapsed or refractory BRAF mutation positive malignant melanoma and is being investigated in various other malignancies. The RAS/RAF/MEK/ERK (MAPK) pathway is critical to cell proliferation in many human cancers. The mTOR inhibitors are well known to exert profound …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
<p><strong>Introduction:</strong> BRAF V600E mutations are associated with poor clinical outcomes for patients with metastatic colorectal cancer (mCRC). Unlike other tumors with the same mutation, BRAF inhibitors are ineffective as monotherapy. CRC tumors with BRAF V600E mutations are associated …
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
<p>The QClamp® BRAF Codon Specific Mutation Detection Kit is a real-time PCR assay for the detection of somatic mutations in codon 600 Valine at exon 15 in the BRAF gene which encodes the serine/threonine protein kinase, using purified DNA. The V600E mutation is the most common BRAF gene mutation …
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Investigation of microRNA expression in thyroid carcinoma among South Africa patients
… outcome in thyroid cancer, which include mutations in the BRAF and RAS genes. In addition to genetic variation, recent studies have reported on the effects of micro-ribonucleic acids' (miRNAs) differential expression observed in tumour and normal tissue as another possible marker of …
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A cohort study of sex differences and prognostic biomarkers in colorectal cancer
… situ hybridization. In addition, KRAS and BRAF mutational status was assessed by pyrosequencing. Associations with clinicopathological and investigative factors were explored by Chi Square and Spearman’s correlation tests, and Kaplan-Meier analysis and Cox proportional hazards modelling …
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Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer
… status of the tumours was investigated. KRAS/BRAF mutation status was assessed by pyrosequencing. Interestingly, we found that obesity was associated with an increased risk of more advanced CRC, i.e. tumour (T)-stage 3 and 4, lymph node positive and metastatic disease, predominantly in men. …
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Identification of novel determinants of primary and acquired resistance to EGFR-targeted therapies in colorectal cancer
… IV CRC patients that do not exhibit a RAS or BRAF mutation. Despite this, it has been shown that while RAS/BRAFWT patients initially respond to cetuximab treatment, resistance to the EGFR mAb can occur ~3-18 months following initial challenge. With regard to both innate and acquired resistance …