Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"BPDE"”.
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Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy
… of benzo[a]pyrene-7,8-diol-9,10- epoxide (BPDE) in human lung tissue and human bronchial epithelial cell histones and DNA and in human serum albumin. The presence of BPDE adducts in human lung tissue and human bronchial epithelial cell histones and DNA was proven by cryogenic fluorescence …
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Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
… the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation.
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Role of TLS Polymerases in Replication of DNA Lesions in Human Cells
… particularly benzo(a)pyrene-diolepoxide (BPDE), a polycyclic aromatic hydrocarbon strongly associated with carcinogenesis, particularly lung cancer. Alkylating lesions result from exposures to endogenous methylating agents and naturally occurring methyl halides. They might interfere with …
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PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… compounds such as Benzo[a]pyrene diol epoxide (BPDE), a metabolite of benzo[a]pyrene. In non-replicating cells, data from the literature and previous work in our laboratory has shown that the Exonuclease 1 (EXO1) is recruited on the single-strand DNA (ssDNA) ends generated by the endonucleolytic …
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Assessment of exposure and effects associated with polycyclic aromatic hydrocarbon contamination in south Chattanooga, Tennessee
… sites. Preliminary results suggest more BPDE-DNA adducts are present in mice from the reference site population than the contaminated site, possibly indicating increased detoxification of PAHs or r epair of DNA damage in mice from the contaminated site. Further validation of this data is …