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Showing 1 to 20 of 23 for “"BNCT"”.
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Construction and characterization of a fission converter based epithermal neutron beam for BNCT
… a source of epithermal neutrons suitable for BNCT. The final design, construction and characterization of a new epithermal neutron beam is presented. A high intensity source with low contamination is obtained using a fission converter driven by thermal neutrons from the MIT research reactor. …
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Spectral characterization of accelerator-based epithermal neutron beams for BNCT and BNCS using neutron activation foils
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1999.
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The design of an intense accelerator-based epithermal neutron beam prototype for BNCT using near-threshold reactions
Near-threshold boron neutron capture therapy (BNCT) uses proton energies only tens of keV above the (p,n) reaction threshold in lithium in order to reduce the moderation requirements of the neutron source. The goals of this research were to prove the feasibility of this near-threshold concept for …
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Computational aspects of treatment planning for neutron capture therapy
Boron Neutron Capture Therapy (BNCT) is a biochemically targeted form of binary radiation therapy that has the potential to deliver radiation to cancers with cellular dose selectivity. Accurate and efficient treatment planning calculations are essential to maximizing the efficacy of BNCT and …
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Comparison of doses to normal brain in patients treated with boron neuron capture therapy at Brookhaven National Laboratory and MIT
A number of boron neutron capture therapy (BNCT) clinical trials are currently underway around the world. Due to the small number of patients at each of the individual centers, it is desirable to pool the clinical data from each into one patient database. Before this can be done, a number of …
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Synthesis, characterization and biological studies of carboranyl-porphyrin bioconjugates for treatment of brain tumors
… barrier (BBB), boron neutron capture therapy (BNCT) for brain tumors, application of carboranyl derivatives in attempt to treat brain tumors using BNCT. Chapter 2 involves synthesis, characterization and toxicity studies (In vitro and In vivo) of high boron containing pegylated …
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Design, construction and installation of a mechanical shutter and design of a medical room door support system for BNCT facility at the MIT's reactor
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
Boron Neutron Capture Therapy (BNCT) is a binary cancer radiation therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal …
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Hypoxia-selective compounds for boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal …
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Nanoparticles For Biomedical Applications
… agent for boron neutron capture therapy (BNCT). A tumor-specific targeting ligand, folic acid (FA), was conjugated to polyethylene glycol to produce a folate-functionalized liposome for improved targeted delivery and accumulation of boron in cancer cells. Cellular uptake monitored by …
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Boron neutron capture therapy treatment planning improvements
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations …
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High Resolution Quantitative Auto-Radiography to determine microscopic distributions of B-10 in neutron capture therapy
The success of Boron Neutron Capture Therapy (BNCT) is heavily dependent on the microscopic distribution of B-10 in tissue. High Resolution Quantitative Auto-Radiography (HRQAR) is a potentially valuable analytical tool due to its ability to simultaneously visualize boron distributions and tissue …
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Syntheseses [sic] and evaluation of porphyrin derivatives for applications in medicine and in material science
… for the boron neutron capture therapy (BNCT) of tumors. Using an efficient and high yield ring-opening reaction, N-substituted porphyrins were also synthesized. The spectroscopic and structural properties of these compounds are presented. These high percentage boron and amphiphilic …
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Beam characterization for accelerator-based boron neutron capture therapy using the ⁹Be(d,n) nuclear reaction
… boron neutron capture therapies (AB-BNCT) was investigated. The moderated neutron spectra produced at several deuteron bombarding energies were evaluated in terms of dose rates and dosimetric profiles in a water-filled brain phantom using an existing heavy water moderator and lead …
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The effect of temperature on the bystander effect as examined in human prostate carcinoma cells with alpha particle irradiation
… therapies such as boron neutron capture therapy (BNCT) and tumor radioimmunotherapy and could provide a means to improve these therapies.
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Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells
… therapies such as radioimmunotherapy and BNCT. This project consists of an engineering part and a biological part. In the engineering part, an apparatus for alpha-particle irradiation of cells was designed and constructed. Dosimetry of this irradiator was conducted. The average dose rate …
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Biological dosimetry of neutron beams for neutron capture therapies
… trials of boron neutron capture therapy (BNCT), and the boron neutron capture synovectomy (BNCS) facility at MIT. The biological dosimetry methodology developed included in vitro irradiation of rodent cells at various depths in a water-filled phantom that simulated healthy tissue. These …
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Ein neues Therapieschema für Glioblastoma Multiforme : Ergebnis einer Analyse heutiger Behandlungskonzepte sowie der Biologie und Genetik des Tumors
… irradiation, application of neutrons or BNCT, a plethora of chemotherapeutics, as well as novel gene and immunotherapy concepts. This has led to a new proposal with carbon-based ion beam therapy as central element. The multimodality regimen comprises surgery and adjuvant therapy, as well. …
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Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy
… formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and boronophenylalanine (BPA). In vitro evaluations utilized a colorimetric assay and 96-well plates to minimize the quantities of …
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