Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"BMSCs"”.
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Homing of 111In-Labeled Bone Marrow Mesenchymal Stem Cells in Acute Brain Trauma Model
… bone marrow-derived mesenchymal stem cells (BMSCs) in an acute brain trauma model by 111In-tropolone labeling and to perform the effect of 111In-labeling on the viability and functions of BMSCs. Rat BMSCs were labeled with 37 MBq 111In-tropolone. Their labeling efficiency and in vitro …
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In vivo bone formation using Adipose Derived Stromal Stem Cells. The histomorphometry of the ovine defect model
… (ADSCs) and Bone Marrow Derived Stem Cells (BMSCs), examined the in vivo osteogenic potential of the ovine ADSCs population and compared it to the in vivo osteogenic potential of ovine BMSCs. The pilot study used both cell populations, expanded and osteogenically stimulated ex vivo and mixed …
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Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
… by encapsulating bone-marrow-stromal cells (BMSCs) and incorporating chondrogenic cues to stimulate differentiation and neotissue production. To test the hypothesis that self-assembling peptide hydrogels provide cues which enhance the chondrogenic differentiation of BMSCs, a technique for …
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Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
… (BM) niches, where BM mesenchymal stromal cells (BMSCs) become a source of eIF4A-cap-dependent translation machinery that is transferred to AML cells via extracellular vesicles (EVs), to meet their translational demands. In two independent models of highly chemo-resistant AML driven by MLL-AF9 or …
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Bionanoparticles as Viable Substrates to Promote Osteogenic Differentiation of Bone Marrow Stromal Cells
<p>Bone marrow stromal cells (BMSCs) have the potential to differentiate into osteoblasts, chondrocytes, adipocytes and smooth muscles. Although, they have shown great prospects in therapeutic and medical applications, less is known about the role that the nano environment plays on their …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
… marrow niches. The bone marrow stromal cells (BMSCs) constitutively secrete the CXCR4 ligand CXCL12, thus attracting leukemia cells and protecting them from cytotoxic drugs, a mechanism that might be responsible for minimal residual disease after conventional chemotherapy against B-ALL. Indeed, …
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Optimizing chondrogenic factors and protein delivery methods for cartilage repair
… tissue production by bone marrow stromal cells (BMSCs), but the mechanisms underlying BMSC response to Dex are not understood. The hypothesis that the addition of Dex to chondrogenic medium would affect matrix production and aggrecanase activity of human and bovine BMSCs in RAD and agarose …
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Effect of Mechanical Environment on the Differentiation of Bone Marrow Stromal Cells for Functional Bone Tissue Engineering
… cells such as bone marrow stromal cells (BMSCs). Part two of the engineering strategy, the biomaterial scaffold, can be fabricated with the appropriate mechanical properties using a synthetic polymer system with tunable properties like polyurethanes. Finally, BMSCs seeded within the …
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Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering
… three steps: seeding bone marrow stromal cells (BMSCs) onto electrospun scaffolds, processing them into cords that allow cell infiltration, and conditioning them with uniaxial cyclic stretch. These steps were addressed in three complimentary studies to establish new methods to engineer a tissue …
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The role of the bone marrow niche and G-CSF in osteochondral repair
… marrow niche mesenchymal stem/stromal cells (BMSCs) contribute to haematopoietic stem and progenitor cell (HSPC) maintenance and the dynamics of this are disrupted by osteochondral repair procedures. In addition, the bone marrow niche can be further manipulated by the HSPC mobilising agent …
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Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. They have cited enthusiasm in the cell therapy community not only for their …
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Osteogenic and chondrogenic differentiation of rat bone marrow stromal cells in 3D culture with novel PCL-TCP scaffolds
… and pore size. After expansion in vitro, BMSCs were enzymatically lifted and then seeded with fibrin glue as cell suspensions into PCL-TCP scaffolds. The cell-scaffold constructs were cultured for 3 weeks in vitro. Cell viability, morphology, and distribution were examined by …
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Engineered N-cadherin substrates for stem cell differentiation
… the gels, with the bone marrow stromal cells (BMSCs) showing the best adhesion properties. This study thus demonstrates that N-cadherin substrates can be used to promote cell adhesion, and may be useful for differentiation studies with BMSCs.
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Engineering biomaterial surfaces with N-cadherin
… into clusters of bone marrow stromal cells (BMSCs) to examine their effects on cellular secretion of vascular endothelial growth factors and subsequent vascular network formation (Chapter 3). The soluble N-Cadherin was also used to modulate neural differentiation of BMSC clusters (Chapter 4). …
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Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue
… by animal-matched bone marrow stromal cells (BMSCs) and chondrocytes seeded in peptide hydrogel were evaluated for their age-associated structure and nanomechanical properties. Independent of age, BMSCs produced longer core proteins and GAG chains than the chondrocytes, suggesting that the …
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The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… and primary bone marrow mesenchymal stem cells (BMSCs). Five fractions of ethyl acetate extract of poncirus trifoliata through column chromatography over a silica gel eluting in gradient system and combined based on their thin layer chromatography (TLC) pattern. Fourth subfraction (E4) of ethyl …
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Tracking of Transplanted Mesenchymal Stem Cells Labeled with Fluorescent Magnetic Nanoparticle in Liver Cirrhosis Rat Model with 3T MRI
… 4 days off) for 3 weeks. Approximately 3.0 x 106 BMSCs suspended in 0.5mL phosphate-buffered saline were slowly injected into the inferior tip of the spleen in group 1 (MNP-labeled BMSCs, n=6) and group 2 (unlabeled BMSCs, n=4). For stem cell tracking, transverse T2*-weighted gradient echo (26/9 ; …
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Investigating the role of PKC-β in tumour activated stromal cells
… that PKC-β inhibitors antagonise activation of BMSCs to a cancer associated fibroblast (CAF)-like phenotype. In-vivo expression of PKC-β was confirmed in fibroblasts of both human and murine cancers. Translationally, microenvironmental PKC-β enhanced tumourigenesis in a murine lung cancer model …
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Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
… culture of bovine bone marrow stromal cells (BMSCs) which can differentiate into chondrocytes, undergo chondrogenesis, and produce cartilage tissue. So far, differences in cell morphology that characterize chondrogenesis had been observed in peptide hydrogels like KLD and RAD but not in the …
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Vasculogenic Scaffolds: How Cell-Cell and Cell-Matrix Interactions Regulate Vascular Differentiation and Morphogenesis
… cells (HUVECs) and rat bone marrow stem cells (BMSCs). The vaculogenesis as well as levels of SMαA and vWF expression were determined using confocal microscopy. This analysis of the two scaffolds showed that cells seeded onto the VM exhibited more rapid vasculogenesis than cells seeded on the …
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