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Showing 1 to 20 of 22 for “"BMSC"”.

  1. In-vitro Modelling of Stromal and Immune Cell Interactions Following Surgical Bone Marrow Stimulation

    Frankham-Wells, Sophie LouiseUniversity of Cambridge2019

    … haematoma containing Bone Marrow Stromal Cells (BMSC) and immune cells at the joint surface, leading to repair. However, the quality of repair after marrow stimulation is, at present, sub-optimal. BMSC are known to interact with immune subpopulations during repair, although the consequences of …

    cambridge Repository record

  2. Nonviraler Transfer von Wachtumsfaktorgenen in humane stromale Knochenmarkzellen zur rekonstruktiven Chirurgie

    Wallmichrath, Jens Christian

    … EGF gilt für stromale Knochenmarkzellen (engl. BMSC) als Mitogen und fördert zusätzlich die für die Ossifikation essentielle Angiogenese in vivo. Rekombinantes EGF erwies sich in unseren Proliferationsexperimenten als mitogen wirksam auf BMSC in vitro. Abhängig vom Donor des Zellmaterials und …

    freiburg-diss Repository record

  3. Investigating the role of PKC-β in tumour activated stromal cells

    Timmins, MatthewUniversity of Cambridge2024

    … shown PKC-β to be a bone marrow stroma cell (BMSC) - autonomous signalling pathway critical for survival of malignant B-cells. PKC-β dependent cell contact factors have been shown to regulate drug resistance, but the role of soluble-factors for this protection remains unknown. Moreover, the …

    cambridge Repository record

  4. Polypyrrole : an interactive substrate for bone regeneration

    Rahman, Nahid, S.M. Massachusetts Institute of Technology.Massachusetts Institute of Technology1998

    … In this study, Bone Marrow Stromal Cells (BMSC), which are the progenitor cells to bone cells (osteoblasts), were used as the in vitro model system. Their viability, proliferation and differentiation capabilities were evaluated on polypyrrole, in the absence and presence of electrical …

    mit Repository record

  5. Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue

    Lee, Hsu-YiMassachusetts Institute of Technology2010

    … by animal-matched bone marrow stromal cells (BMSCs) and chondrocytes seeded in peptide hydrogel were evaluated for their age-associated structure and nanomechanical properties. Independent of age, BMSCs produced longer core proteins and GAG chains than the chondrocytes, suggesting that the …

    mit Repository record

  6. Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery

    Kopesky, Paul WayneMassachusetts Institute of Technology2009

    … by encapsulating bone-marrow-stromal cells (BMSCs) and incorporating chondrogenic cues to stimulate differentiation and neotissue production. To test the hypothesis that self-assembling peptide hydrogels provide cues which enhance the chondrogenic differentiation of BMSCs, a technique for …

    mit Repository record

  7. Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process

    Coan, Heather Adeline BradburyWake Forest University2011

    … as bone marrow-derived stem cells (BMSC), the mechanisms and pathways that these cells utilize to differentiate down the osteogenic pathway are still unclear. Specific differences exist between BMSC and ADSC osteogenesis; however more detailed analysis of how the two MSC types differ …

    wfu Repository record

  8. Wirkungsweise von Bisphosphonaten auf die Expression verschiedener Knochenmarker in mesenchymalen Stammzellen der Plazenta

    Kemper, Götz2012

    … für die Gewinnung von mesenchymalen Stammzellen (bMSC) wurde u. a. die menschliche Plazenta beschrieben. Die charakterisierten sogenannten mesenchymalen Stammzellen der Plazenta (pMSC) sind denen des Knochenmarks funktionell sowie phänotypisch ähnlich. In dieser Arbeit wurden pMSC isoliert, …

    goettingen Repository record

  9. Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy

    Rennerfeldt, Deena Antoinette.Massachusetts Institute of Technology2019

    Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. They have cited enthusiasm in the cell therapy community not only for their …

    mit Repository record

  10. Osteogenic and chondrogenic differentiation of rat bone marrow stromal cells in 3D culture with novel PCL-TCP scaffolds

    SHI ZHENG2005

    … of rat bone marrow stromal cells (BMSC) in 3D PCL-TCP scaffolds. PCL-TCP scaffolds fabricated by fused deposition modeling (FDM), are honeycombed, highly reproducible bioresorbable 3D structures with a completely interconnected pore network and custom-tailored porosity and pore …

    nus Repository record

  11. Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy

    Lisi-Vega, Livia EUniversity of Cambridge2024

    … (BM) niches, where BM mesenchymal stromal cells (BMSCs) become a source of eIF4A-cap-dependent translation machinery that is transferred to AML cells via extracellular vesicles (EVs), to meet their translational demands. In two independent models of highly chemo-resistant AML driven by MLL-AF9 or …

    cambridge Repository record

  12. Complementary strategies to promote the regeneration of bone-ligament transitions using graded electrospun scaffolds

    Samavedi, SatyavrataVirginia Tech2013

    … gradients in bone marrow stromal cells (BMSCs), and thus aid the regeneration of B-L transitions in the long-term. Towards the eventual goal of regenerating complex tissue transitions, this project employs three complementary strategies to fabricate graded scaffolds. The three strategies …

    vt Repository record

  13. Development and characterisation of a Portland cement-based dental root filling material

    O'Beirne, Joanne L.University of Birmingham2011

    … Similar in vitro responses of adult and neonatal BMSC, periosteal and osteoblastic cultures were noted with PoP-modified and unmodified cements. Inhibition of cell growth was seen with 3day-cultures containing modified model cements and MTA, the possible result of calcium hydroxide release from …

    birmingham Repository record

  14. ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE

    Sharma, SambadWake Forest University2016

    … expression of BMP7 in bone marrow stromal cells (BMSC). The secreted BMP7 then kept cancer cells in a dormant state by inducing senescence, reducing stemness and activating dormancy-associated p38 MAPK signaling and p21 expression in cancer cells. Importantly, we found that SPARC was …

    wfu Repository record

  15. Engineering biomaterial surfaces with N-cadherin

    Vega Leonel, Johana CarolinaUniversity of Illinois at Urbana-Champaign2015

    … into clusters of bone marrow stromal cells (BMSCs) to examine their effects on cellular secretion of vascular endothelial growth factors and subsequent vascular network formation (Chapter 3). The soluble N-Cadherin was also used to modulate neural differentiation of BMSC clusters (Chapter 4). …

    uiuc Repository record

  16. The role of the bone marrow niche and G-CSF in osteochondral repair

    Beaton, Francesca EmilyUniversity of Cambridge2019

    … marrow niche mesenchymal stem/stromal cells (BMSCs) contribute to haematopoietic stem and progenitor cell (HSPC) maintenance and the dynamics of this are disrupted by osteochondral repair procedures. In addition, the bone marrow niche can be further manipulated by the HSPC mobilising agent …

    cambridge Repository record

  17. Development of Jetting Techniques for the Delivery of Mesenchymal Stromal Cells for Therapeutic Applications

    McCrea, ZitaNational University of Ireland Maynooth2015

    … mouse bone-derived mesenchymal stromal cells (mBMSC) at a cellular and immunological level. Known characterisations of MSC, i.e. expression of specific surface markers, suppression of T- cell activation, multilineage differentiation, and the pro-reparative properties were analysed for BES BMSC. …

    maynooth Repository record

  18. Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering

    Bashur, Christopher AlanVirginia Tech2009

    … three steps: seeding bone marrow stromal cells (BMSCs) onto electrospun scaffolds, processing them into cords that allow cell infiltration, and conditioning them with uniaxial cyclic stretch. These steps were addressed in three complimentary studies to establish new methods to engineer a tissue …

    vt Repository record

  19. Optimizing chondrogenic factors and protein delivery methods for cartilage repair

    Florine, Emily MarieMassachusetts Institute of Technology2012

    … tissue production by bone marrow stromal cells (BMSCs), but the mechanisms underlying BMSC response to Dex are not understood. The hypothesis that the addition of Dex to chondrogenic medium would affect matrix production and aggrecanase activity of human and bovine BMSCs in RAD and agarose …

    mit Repository record

  20. Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture

    Bogers, Sophie HelenVirginia Tech2017

    … activities of bone marrow derived MSCs (BMSCs) are enhanced by three-dimensional spheroid culture so equine BMSC (eBMSC) spheroids could inhibit intra-articular inflammation. The overarching hypothesis is that eBMSCs can be enhanced to produce an allogeneic eBMSC therapy that inhibits …

    vt Repository record

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