Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"BMP7"”.
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Papel de los fibroblastos peritumorales en la progresión del cáncer de páncreas humano: estudio del gen erizo
… e invasión tumoral y la eficacia de la proteína BMP7 en el cáncer de páncreas. MATERIAL Y MÉTODOS Utilizamos como modelo animal ratones inmunodeprimidos, SCID y nude. Realizamos xenotrasplantes para analizar los resultados. Se cultivaron los fibroblastos normales, peritumorales y tumorales, “in …
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ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… which significantly stimulated the expression of BMP7 in bone marrow stromal cells (BMSC). The secreted BMP7 then kept cancer cells in a dormant state by inducing senescence, reducing stemness and activating dormancy-associated p38 MAPK signaling and p21 expression in cancer cells. Importantly, we …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… transformation. We discovered that MDM2, BMP7 and Bmi-1 were overexpressed in the tumorigenic HPDE cells, and that Smad4 played important roles in regulation of BMP7 and Bmi-1 gene expression and the tumorigenic transformation of HPDE cells. IPA signaling pathway analysis of microarray …
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… pancreatic bud during pancreatic development. Bmp7, BmpR1a, and BmpRII are expressed in the pancreatic endoderm during pancreatic bud development. Bmp2, Bmp4, BmpR1a and BmpRII are expressed in the dorsal aorta which transiently flanks the pancreatic bud. Bmp4, Bmp7, BmpR1a, BmpR1b, and BmpRII …
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Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
… will also be studied including TGF-β, BMP7 and IL-33. Results showed that phytoestrogens genistein and daidzein significantly reduced prostate cancer cell viability (PC3 cells) with concentration 10-7 M (15 %, P = 0.01) and 10-6 M (11%, P = 0.04) for genistein and for daidzein the …
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Bmp-Signaling Regulates A Common Transcriptional Program to Control Facial Form and Skeletal Morphogenesis
… of <em>Bmp2</em>, <em>Bmp4</em>, and <em>Bmp7</em>, resulted in complete or partial loss of multiple CNC derived skeletal elements revealing a critical requirement for Bmp-signaling in membranous bone and cartilage development. Importantly, the BIG signature was reduced in Bmp loss of …
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EFFECTS OF OSTEOARTHRITIS AND INFLAMMATION ON MENISCUS CELL RESPONSE TO OSTEOGENIC PROTEIN 1 (OP1)
… (BMP) family member, Osteogenic Protein 1 (OP1/BMP7) in meniscus cells. We have focused on the meniscus, because this tissue is highly susceptable to injuries which often fail to heal and lead to osteoarthritis (OA). OA is driven by molecular inflammation which disrupts tissue homeostasis …
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
… recent GWAS study [3] identified association of BMP7 with testicular dysgenesis syndrome; however the molecular mechanisms behind this association remain unknown. Previously, we described the development of testicular germ cell tumors in zebrafish carrying a mutation in bmpr1bb, a BMP family …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… Snai1 and Twist, and signaling molecules Bmp2, Bmp7, Notch2, Jag1 and Wnt2In addition, we show that the canonical Wnt signaling pathway contributes to the vessel-forming potential of the allantois. Ex vivo, the Tbx4 mutant phenotype can be rescued using agonists of the Wnt signaling pathway and …
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Model for tooth development in vitro
… Dentin sialophosphoprotein, TGFß1, Activin, and BMP7. Inductive abilities of the self-organized dental mesenchyme were evidenced in co-culture with epithelial cells, that exhibited invagination and cytodifferentiation. The presented model of tooth development fulfills all demands on a functional …
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
… The proliferating epithelial cells release BMP7 which, in turn, promotes fibroblast proliferation. Interestingly, we demonstrated that this signaling cross-talk is specific to FSP1+ fibroblasts, highlighting the importance of fibroblast heterogeneity not only in cancer progression, but also …
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Studio del pathway della Displasia Ectodermica Anidrotica (EDA)
… expression changes for 3 selected genes, Tbx1, Bmp7, and Jag1, both in primary keratinocytes and in Wild-type and Tabby whole skin, by Q-PCR and Western blotting analyses. Thus, this study detected novel candidate pathways downstream of EDA. In the second part of the research project, plasmid …