Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"BMP4"”.
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The effects of BMP4 on different in vitro models for mouse gastrulation and neural induction
Bone morphogenetic protein 4 (BMP4) is a signaling protein involved in several key developmental processes, including gastrulation and neural induction. Gastrulation is an event that changes the topology of the embryo, organising a single layer or ball of cells into the three primordial germ …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… the active form of bone morphogenetic protein-4 (BMP4) is transiently and acutely upregulated after injury. BMP4 is a key signaling protein that regulates embryogenesis and neurodevelopment. BMP4 has also been implicated in modulating glial scarring and remyelination in sub-acute and chronic SCI …
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Bmp-Signaling Regulates A Common Transcriptional Program to Control Facial Form and Skeletal Morphogenesis
… roles in normal craniofacial development, and Bmp4 deficiency results in craniofacial abnormalities, such as cleft lip and palate. We performed an in depth analysis of <em>Bmp4</em>, a critical regulator of development, disease, and evolution, in the CNC. Conditional <em>Bmp4</em> …
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NOGGIN Transport in a Model Human Epiblast
… Brivanlou/Siggia labs previously showed that (i) BMP4 initiates the cascade of events leading to gastrulation; (ii) BMP4 signal-reception is restricted to the basolateral domain; and (iii) in a human-specific manner, BMP4 directly induces the expression of NOGGIN. In this work, I interrogate the …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… murine airway epithelial cells (MAECs). BMP2 and BMP4 inhibited E-cadherin expression in BEAS-2B cells. In addition, BMP4 induced an epithelial-mesenchymal transition (EMT) in BEAS-2B where cells acquired a mesenchymal phenotype including fibroblast-like morphology and increased mesenchymal gene …
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Strategies to Target the Bone Morphogenetic Protein Signalling Pathway in Lung Disease
… drug compound molecules. We also looked for BMP4 disregulation in a number of different animal models to help ascertain the role of the pathway in the progression of disease and damage in the lung. BMP4 has been shown to have a role in the induction of EMT in MAECS (E.Molloy) and to play a …
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Development of a reversible quiescence model to identify signals enabling glioblastoma cancer stem cell transition between active and quiescent states
… model using Bone Morphogenetic Protein 4 (BMP4) in combination with Fibroblast Growth Factor 2 (FGF2) for different durations (3, 4), to model different depths of quiescence. BMP4 plus FGF2 treatment results in cell cycle exit, downregulation of protein synthesis, a key hallmark of …
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Elektroporation: Eine Methode zur Transfektion von Wirbeltierembryonen
… Über-expressionsstudien die Rolle von Geminin, BMP4 und DlX5 in den Muster-bildungsprozessen, die zur Anlage der Neuralplatte und zur Segregation von neuralen und epidermalen Identitäten im Ektoderm führen, untersucht. Es konnte gezeigt werden, daß ektopisch exprimiertes BMP4, ein TGF-o Faktor …
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Topographie molekularer Faktoren der Keimzellentwicklung während der frühembryonalen Entwicklung des Kaninchens
… der Schlüssel-Gene Blimp1, BMP2 und BMP4 untersucht und mit aus dem Mausmodell bekannten Daten verglichen. Für die Untersuchungen wurde das Kaninchen als Modellorganismus ausgewählt, weil es mit seiner flachen Keimscheibe für den Säugerembryo besonders repräsentativ ist und aufgrund …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 mitogen-activated protein kinase proteins and promoted BMP4-induced SMAD-dependent by increasing the phosphorylation of BMP4-induced SMAD1/5 protein expressions. Also, these catechin compounds increased id1 target …
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Characterisation of BMP Processing and Signalling in Adipocytes
… In my final year, my thesis expanded to compare BMP4, BMP9, and BMP10 signalling in adipocytes. BMP4 has a well-documented function in adipocytes, whereas roles for BMP9 and BMP10 are less known. Despite BMP9 and BMP10 having almost identical signalling activities in vascular endothelial cells, …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… demonstrate that hdac3 functions downstream of bmp4 signaling and is specifically required for primitive erythropoiesis. We also describe here that runx1 is activated by bmp4 in an HDAC-dependent manner. Consistent with this, restoring runx1 expression partially rescues VPA mediated …
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The voltage gated calcium channel β2 protein is required in the heart for control of cell proliferation and heart tube integrity
… by smaller heart fields and an increase in bmp4, an anti-proliferative marker. Thus, β2.1 helps regulate heart size by regulating the rate of mitosis and bmp4 expression in the ventricle. Additionally, cardiomyocytes depleted for β2.1 failed to accumulate N-cadherin at the membrane, and …
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… comprised treatment of cultured cells with BMP4 and/or retinoic acid (RA), with subsequent quantitative RT-PCR and immunocytochemistry analysis for downstream BMP4- and RA-response genes, and liposomal-mediated transfection of cells with a DAZL overexpression plasmid to assess their …
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… during pancreatic bud development. Bmp2, Bmp4, BmpR1a and BmpRII are expressed in the dorsal aorta which transiently flanks the pancreatic bud. Bmp4, Bmp7, BmpR1a, BmpR1b, and BmpRII are expressed in the pre-pancreatic mesenchyme. Interestingly, Bmp4 is expressed asymmetrically along the …
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… The HDDA scaffolds loaded with growth factors BMP4 and VEGF and zein scaffolds loaded with growth factors BMP4 and FGF10 were implanted in the critical defect site in the tarsus of the Xenopus Laevis. Defects in control frogs were left empty. Fractures were also induced in some frogs to study …
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Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
… the primary mouse keratinocytes treated with BMP4 and processed for analysis of global miRNA expression using the microarray approach. Microarray and real-time PCR analysis revealed BMP4-dependent changes in the expression of distinct miRNAs, including miR-21, which expression was strongly …
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The role of mechanotransduction in signalling and pluripotent stem cell fate
… gels significantly enhanced the response to BMP4 and increased mesoderm differentiation. Activation of SMAD1/5, the effector of the BMP4 pathway, was found to be enhanced and differentially patterned between gels and plastic. To further dissect the mechanisms by which StemBond gels …
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Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors
… arrangement. The iTr spheres respond to BMP4, EGF, and FGF2 by phosphorylating signal transduction proteins. Addition of BMP4, EGF, or FGF2 in combined pairs was able to alter TFAP2A, NEU1, and SLC35A1 expression. The generation of iTr cells by transduction of the Yamanaka reprogramming …
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