Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"BMP10"”.
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… which maintains vascular quiescence. BMP9 and BMP10 are the high affinity ligands for this signalling complex. Administering exogenous BMP9 has been shown to reverse disease in animal models of PAH, so the Morrell group is investigating the use of BMP9 as a therapy for PAH. Nonetheless, …
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Characterisation of BMP Processing and Signalling in Adipocytes
… as substituting BMP8B's prodomain with that of BMP10 enhances secretion. ProBMP8B is mainly cleaved at a consensus pro-protein convertase site near the mature ligand domain (R<sub>260</sub>TRR<sub>263</sub>↓), with alternative cleavage sites used when the primary site is unavailable, suggesting …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… protein which is a coreceptor for BMP9 and BMP10. Endothelial-specific, homozygous deletion of Eng in adult mice (Eng-iKOe) has been shown to model the HHT phenotype, with the development of arteriovenous malformations (AVMs) in the pubic symphysis, associated high-output heart failure, via …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… presented in this thesis confirms that BMP9 and BMP10 treatment of pulmonary microvascular endothelial cells (PMECs) increases *SEMA3G* expression 5-10-fold. Knockdown of BMP signalling pathway components revealed that BMP9/10 regulated *SEMA3G* expression via the canonical Smad signalling …