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Showing 1 to 8 of 8 for “"BMP-7"”.
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Bone morphogenetic protein (BMP-7) και μοριακά δίκτυα δυνητικών stem κυττάρων στον νεφρό
Η BMP-7 αποτελεί μόριο κλειδί κατά την εμβρυογένεση στον νεφρό, ενώ μετέπειτα, θεωρείται νεφροπροστατευτικός παράγων. Ο νεφρός χαρακτηρίζεται από μία μοναδική πλαστικότητα μεταξύ επιθηλιακών και μεσεγχυματικών κυττάρων. Κατά την ανάπτυξη του Νεφρού, το επιθήλιο του νεφρώνα δημιουργείται μέσω της …
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Einfluss von BMP-7 und Endoglin auf den TGF-beta Signalweg bei fibrosierenden Lebererkrankungen
… doctoral thesis was to analyze the influence of BMP-7 on the TGF-b1 pathway and to characterize the role of endoglin within these two pathways. Using the endoglin deficient myoblast cell line L6E9 it was possible to show the antagonistic character of these two cytokines and further to determine …
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Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
… interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in recombinant form for local application in nonunions and stimulate differentiation and proliferation of osteoblasts. However, BMPs also induce osteoclastic activation, which …
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Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
… hypothesis was that by adding bone-inductive BMP-7 to the bisphosphonate, new bone formation would also be stimulated, leading to an increase in stability. In papers I and II, the effect of the bisphosphonate zoledronate and BMP-7 on allografts was investigated in a bone conduction chamber in …
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Pharmacological manipulation of fracture healing and bone remodeling
… either pretreated with a bone inducing protein, BMP-7 or saline before surgery. As BMP-7 also induces resorption, the rats received either an injection of zoledronate or saline after two weeks. We saw that weekly injections of zoledronate decreased the resorption of both old graft and new-formed …
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Einfluss von niederenergetischem gepulsten Ultraschall auf das Proliferations- und Differenzierungsverhalten osteoblastärer Zellen in vitro
… Phosphatase, Typ-I-Kollagen, Osteokalzin, BMP-2, BMP-4, BMP-7, COX-2 und HSP 47. Abgesehen von BMP-7 wurden alle der genannten Gene sowohl in der Ultraschall- als auch in der Kontrollgruppe exprimiert. Eine qualitative Änderung des Expressionsmusters unter Ultraschall kann somit …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… the impact of endoglin on the TGF-beta and the BMP pathways. TGF-beta1 and BMP-7, which are ligands for endoglin, are important cytokines in the formation and the development of liver fibrosis. Stimulation experiments were performed using TGF-beta1 and BMP-7. Reporter gene assay andWestern blot …
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Distraction of Heterotopic Bone Formed with BMP-2 in a Rat Model: The Technique
… when bone morphogenic proteins (for example BMP-2 and BMP-7) and a collagen matrix are surgically placed in a rat model either orthotopically or heterotopically. Bone begins to form by the 14 day, and is at it maximum calcified state by the 21st day. The purpose of this study is to observe …