Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"BMP signaling pathway"”.
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Spatio-temporal investigation and quantitative analysis of the BMP signaling pathway
Bone Morphogenetic Proteins (BMPs) are key regulators for a lot of diverse cellular processes. During embryonic development these proteins act as morphogens and play a crucial role particularly in organogenesis. BMPs have a direct impact on distinct cellular fates by means of …
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Development of BMP type I receptor kinase inhibitors for the treatment of fibrodysplasia ossificans progressiva and the study of the BMP signaling pathway
The BMP signaling pathway is essential for embryonic development and the maintenance of tissue homeostasis. Dysregulated BMP signaling, both loss and gain-of-function, has been demonstrated in the pathogenesis of diseases including cancer, atherosclerosis, anemia and particularly hereditary …
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Identification of a novel autonomous role for Ecdysone Receptor during Drosophila ovarian germ cell differentiation
… that these cells remain competent to respond to BMP signals. Using single-cell RNA-sequencing to compare EcR over-expressing and Tkv over-expressing ovaries, we found remarkably similar transcriptomes in heterogenous populations of germ cells. These data suggest that EcR promotes differentiation …
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
… potential and response to treatment. The pathways that determine tumor cell differentiation are not known, impeding the development of new therapies. Thus, the treatment of GCTs has remained static since the introduction 30 years ago of cisplatin which, while effective, causes severe side …
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Developmental Characterization of Cara Mitad: A Drosophila Nuclear Receptor Co-Regulator
… functions in several hormone regulated response pathways. The Drosophila TRR protein is an ortholog of the ALR-1 C-terminus that encodes a histone methyltransferase required for hormone-stimulated transcription. The evolutionary split of ALR-1 raises interesting questions regarding the conserved …
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Analysis of the biochemical mechanisms of heterotopic ossification following musculoskeletal trauma
… likely through the activation of the BMP-2 receptor is a primary pathway leading to heterotopic ossification. However, further research must confirm the underlying cellular and biochemical mechanisms. OBJECTIVES: To compare the development of ectopic bone formation with and without …
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Characterization of Factors Controlling Germline Stem Cell Maintenance in Drosophila Melanogaster
… GSC factors to control CB differentiation pathway. In particular, studies of a key differentiation factor, bam, underscored the important paradigm of maintaining GSC by preventing the initiation of the CB differentiation pathway. The Dpp/BMP signaling pathway from the GSC niche promotes …
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… and remodeling of synapses. Defining the signaling pathways that underlie such plasticity has been a major goal of modern neuroscience. BMP signaling critically regulates both morphological plasticity and neurotransmission in motorneurons at the Drosophila neuromuscular junction (NMJ). …
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QUANTITATIVE MODELING OF SCALING OF PATTERNS AND RECEPTOR SIGNALING IN MORPHOGENESIS
… appropriate proportions and positions. The key signaling factors that guide a number of those processes are known as morphogens. Developing cells sense their respective positional information from a graded morphogen profile, and differentiate into patterns. Remarkably, patterns are highly robust …