Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"BMI1"”.
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… B lymphoma Mo-MLV insertion region 1 homolog (BMI1) is an epigenetic regulator important for stem cell self-renewal and differentiation, and it is also a proto-oncogene that is overexpressed in a wide variety of cancer types. Given its role in normal stem cell biology and its overexpression in …
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Roles for the polycomb group protein BMI1 in lung adenocarcinoma progression and maintenance
The B lymphoma Mo-MLV insertion region 1 homolog (Bmil) protein is implicated as an oncogene in a variety of human cancers. During normal development, Bmil acts as part of a transcriptional repressive complex that regulates processes such as stem cell self-renewal, cell-fate commitment, and …
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PTEN regulates the BMI1-mediated self-renewal of long-term hematopoietic stem cells in developmental and stress conditions
… regulation of HSC homeostasis, I crossed Bmi1GFP/+ knock-in reporter mice, in which the intact Bmi1 promoter drives the transcription of the GFP transgene instead of the self-renewal regulator gene Bmi1, with Pten-deficient mice (Vav-icre+;CD2-C3+;Ptenfl/fl, or vCPΔ/Δ) to generate vCBPΔ/Δ …
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BMI1 is a context-dependent tumor suppressor that is a barrier to dedifferentiation in non-small cell lung adenocarcinoma
… This thesis addresses an epigenetic regulator, Bmi1, which acts in stem cells to maintain their proliferative and self-renewal capacity primarily through silencing of the Ink4a/Arf locus. Bmi1 has been proposed as a good therapeutic candidate in cancer because of its presumed role in maintaining …
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Transcriptional regulators in stem cell biology
… murine leukemia virus integration site 1 (BMI1). BMI1 promotes stemness and tumorigenesis in many tissues through both transcriptional repression of the Cdkn2a locus and other functions. Notably, BMI1 supports melanoma progression by activating epithelial-mesenchymal transition (EMT) …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… cancers, which mainly focuses on its target Bmi1, a Polycomb group protein, and an intestinal stem cell marker. Human colorectal cancers tissue array staining showed that Bmi1 levels are significantly increased in the tumor tissues from colon cancer patients compared with adjacent normal …
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Neue Interaktionspartner der MAPKAP-Kinasen 3pK und MK2
… HPH2 und das Protoonkoprotein Bmi1, als Interaktionspartner identifiziert. Proteine aus der Polycomb-Gruppe (PcG) sind dafür bekannt, multimere, Chromatin-assoziierte Proteinkomplexe zu bilden. Diese wirken als transkriptionelle Repressoren und spielen als solche eine wichtige …
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The Role of Cyp33 in MLL Mediated Gene Repression
… to recruit HDAC1 to MLL (Koonce, M 2004). hPC2, BMI1 and CtBP also bind to the MLL repression domain, although the role these co-repressor proteins play in suppression of MLL target gene activation has not been elucidated (Xia, Z 2003). In this study, the co-repressor proteins (HDAC and BMI1) …
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MiR-128 controls the activity of Polycomb Repressor Complexes 1 and 2 in Neural Stem Cells: Implications of its loss in gliomagenesis.
… show that miR-128 directly targets the mRNA of BMI1 and SUZ12, key components of PRC1 and PRC2, respectively. This blocks the partially redundant functions of PRC1/PRC2, thereby significantly reducing PRC activity and its associated histone modifications. MiR-128 and SUZ12/BMI1 show opposite …
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Cloning and characterization of E2F6, a novel member of the E2F transcription factor family
… including Ringla, Mel-18, mphl, and the oncogene Bmi1. Moreover, overexpression of E2F6 leads to a similar downregulation of p19ARF as exogenous Bmi1. These findings suggest that the biological properties of E2F6 could be mediated through its ability to recruit the polycomb complex.
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Role of Polycomb Group Protein Mel18 in Hematopoietic Stem Cell Maintenance
… PRC1 can also regulate 3D chromatin structure. Bmi1 (PCGF4) and Mel18 (PCGF2) are two major homologs of the PCGF subunit within the canonical PRC1 complex. While Bmi1 is a positive regulator of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) self-renewal, the role of Mel18 in …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… in single TET2/JAK2 mutant HSCs. Of these, Bmi1 and, to a lesser extent, Pbx1 and Meis1 overexpression in JAK2-mutant HSCs could improve stem cell self-renewal, allowing development of a disease phenotype in functional assays. Together, these findings refine the molecules involved in clonal …
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Understanding Nanog'S Role In Cancer Biology
… which includes known oncogenes such as Bmi1 among its authentic targets. Future work will necessarily involve discerning instances in which Nanog mRNA is the biologically relevant molecule, as well as identifying additional mRNA species which may serve solely as a molecular sink for …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… Cdkn2a locus. Loss of Cdkn2a through deletion or Bmi1 overexpression failed to ameliorate the apoptotic response, suggesting that E2A-PBX1 mediated apoptosis occurs independently of Cdkn2a in murine pre-B cells. However, in the absence of Cdkn2a, co-expression of constitutively active MerTK or Ras …
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
… of Id1/3 in 4T1 cells is possibly mediated by Bmi1/Mel18 and TGF-β signalling pathway. Further functional validation is required to confirm this finding.
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Study of Rest As A Negative Regulator of P16Ink4A
… <em>miR-203</em> and Bmi-1. We observed that Bmi1 -expression mirrored that of REST and inversely correlated with that of <em>miR-203</em> in the postnatal cerebellum and <em>in vitro</em> differentiated granule and NSC-M progenitors. In contrast, forced <em>REST</em> transgene expression in …
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Significance of Protein Interactions in Mediating AF9 Function
… Polycomb group PRC1 complex, CBX8, RING1B, and BMI1. The interaction of AF9 with other PRC1 proteins is directly mediated by CBX8 and precludes AF9-DOT1L binding. Knockdown of CBX8 with shRNA leads to decreased ENaCα mRNA levels. In contrast, CBX8 overexpression results in increased ENaCα mRNA …