Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"BMEC"”.
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Establishment of a Novel Patient hiPSC-derived in vitro Blood-Brain Barrier Model of Collagen IV Small Vessel Disease
… brain microvascular endothelial cells (BMEC), mural cells (MC) and astrocytes, the model was used to probe the phenotype of COL4A1/2 SVD. Differentiation of hiPSC into BMEC was extensively optimised to overcome high variability between different hiPSC lines. Once established, hiPSC-BMEC …
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Niche disturbances in Chronic Lymphocytic Leukaemia affect HSC residency and drug resistance
… pathways, as well as BM endothelial cells (BMEC) (Lutzny et al., 2013). This activation provides a nurturing environment, which not only contributes to disease progression, but likely also disrupts normal haematopoiesis, leading to insufficient blood production. I hypothesised that …
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Interaktion von Listeria monocytogenes mit Endothelzellen
… mikrovaskulären Hirnendothelzellen (BMEC) unterscheiden sich aber deutlich von den makrovaskulären HUVEC. In der vorliegenden Arbeit wurde die Interaktion von L. monocytogenes mit HUVEC und mit humanen BMEC (HBMEC) untersucht. Es konnte gezeigt werden, daß L. monocytogenes HBMEC …
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Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
… (SZ). Brain microvascular endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which collectively contribute to maintaining proper BBB function. While previous studies have provided some insights into the role …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… brain-specific microvascular endothelial cell (BMEC) is an essential structural component of the BBB. To test if integrity of the BBB formed by BMECs is compromised in 22q11.2 deletion syndrome (also called DiGeorge syndrome), which is one of the validated genetic risk factors for schizophrenia, …
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The psychosocial and clinical outcomes of surgery for Thyroid Eye Disease (TED)
… patients from Birmingham and Midland Eye Centre (BMEC) to explore expectations of orbital decompression and thematic analysis was performed. Prior to surgery, the regression model explained 55% of the variance in GO-QOL visual function scores and 75% of the variance in GO-QOL appearance scores. …
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Gold Nanoparticles as a Delivery System of Oligonucleotides into the Brain
… endothelial cells (kidney (ciGENC), bone marrow (BMEC) and lung primary (HMVEC-L)) was compared. Kidney endothelium had higher nanoparticle uptake than brain endothelium. Cellular properties that might influence this cell-selective uptake were investigated; the high level of nanoparticle uptake by …
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hiPSC-Derived Cerebral Small Vessel Disease Models
… Brain Microvascular Endothelial Cells (iBMECs), which resulted in decreased TEER levels and increased permeability. They also induced apoptosis, migration defects, and transcriptome changes in hiPSCs-derived Mural Cells (iMCs). A co-culture system made of iBMECs and iMCs revealed that …
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The development of preclinical strategies for facilitation of lead candidate selection
… human brain microvessel endothelial cells (BMECs), however, due to the growing interest in BBB permeation and lack of tissues, the supply is limited. As an alternative method, many groups have investigated the use of primary animal BMECs, usually of murine, porcine, or bovine source. These …