Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"BK channel"”.
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Modulation of Cerebral Artery Smooth Muscle BK Channel Function by Neurosteroids
<p>Voltage-gated and Ca2+ activated K+ channels of large conductance (BK) channels are essential for many key physiological processes, such as controlling the contraction of smooth muscle, including cerebrovascular smooth muscle. Importantly, BK channels are made up of a homotetramer of α subunits …
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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes
… calcium (Ca<sup>2+</sup>)-activated potassium channels (BK) are expressed in arterial myocytes to control arterial contractility. It is composed of pore- forming BKα and auxiliary β1 subunits. Auxiliary β1 subunits associate with BKα which modulate Ca<sup>2+</sup> sensitivity of BK channel. …
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Acclimatization to High-Altitude, Long-Term Hypoxia Alters BK Channel Structure and Function
… possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and splice variation of the …
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Molecular Mechanisms Underlying Alcohol-Induced Cerebral Artery Smooth Muscle BK Channel Inhibition and Eventual Cerebral Vasoconstriction
… calcium-and voltage-gated potassium (BK) channels. Indeed, ethanol (50 mM) decreases the steady-state activity (NPo) of vascular myocyte BK channels leading to an increase in cerebral artery tone. In native tissues, functional BK channels are oligomers of four channel-forming slo1 …
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Regulation of Ca2+-Activated K+ Channel: Changes with Development
… change in response to iberiotoxin, a selective BK channel blocker, is significantly different between adult and fetal VSMCs. Our study of basilar VSMCs in whole-cell preparations showed that the total outward current density of fetal myocytes (57.9 ± 6.7 pA/pF) was greater than that of the adult …
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Cholesterol Modulation of BK Currents and Cerebral Artery Diameter Via Channel-Forming Alpha-Subunit
… and calcium-gated, large conductance potassium channels (BK; MaxiK) are ubiquitously expressed and subsequently mediate numerous physiological processes. Cholesterol is consumed in high amounts with the diet and accumulates in cellular membranes when plasma levels become elevated. Cholesterol is …
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
… of PKG involved with vasorelaxation is the BK channel alpha protein. To examine the influence of LTH on PKG-induced vasorelaxation, and to demonstrate the relative influence of the BK channel in these conditions, we used carotid and middle cerebral arteries from normoxic and chronically …
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The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels.
… calcium- and voltage-activated potassium channel, also known as the Big Potassium (BK) channel as an example, due to its ubiquitous expression and widespread varied role in human physiology, this study aimed to prioritise SNPs with the potential to affect the function of the channel. Using …
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Action of halothane on large-conductance, calcium-activated potassium channels in rat cerebrovascular smooth muscle cells
… of large conductance, Ca²⁺-activated potassium channels (BK channels) in cerebral artery smooth muscle cells. The present experiments utilized extra cellular patch clamp techniques to investigate whether clinically relevant concentrations of halothane directly alter the biophysical properties of …
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RCK Domain Model of Calcium Activation in BK Channels
<p>Potassium ion channels are ubiquitously expressed from bacteria to mammals where they are involved in various processes ranging from the regulation of osmotic pressure in a single cell to the electrical response in muscle fibers to the generation of action potentials in neurons. The BK channel …
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Ca2+-Activated K+ Channels in Urinary Bladder Smooth Muscle: Functional Role and Potential as Therapeutic Targets for Overactive Bladder
… conditions, the opening of potassium (K+) channels causes membrane hyperpolarization and limits the entry of Ca2+ and thus decreases DSM contractility. Among the various K+ channels, Ca2+-activated K+ (KCa) channels are important in regulating DSM function. Based on their biophysical …
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Investigating the Impact of K+ Channel Expression on Mechanosurveillance of Disseminated Cancer Cells
… of the large conductance potassium efflux (BK) channels, as regulators of cellular stiffness downstream of myocardin related transcription factor A (MRTFA). In primary pericytes, KCNMB1 knockdown increased cellular stiffness, which is consistent with the role of potassium efflux in promoting …
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Effect of Long-term Hypoxia on Myometrial Contractility in the Pregnant Sheep
… large-conductance, Ca<sup>2+ </sup>activated (BK) channels activity and protein expression, and cGMP-depended protein kinase (PKG) activity. Myometrium was collected from near-term pregnant sheep exposed to high altitude-associated LTH and from normoxic pregnant controls. After pretreatment …
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Mechanisms of pathological adipogenesis
… including some forms of osteoporosis. Ion channels and ghrelin signalling have been shown to be involved in regulating many cell processes such as proliferation, differentiation and apoptosis, particularly in bone. This thesis investigated the roles of ghrelin and ion channels in the …
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Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
… (Kv) and two-pore-domain (K2P) potassium channels are key points of regulation in many excitable cells. Despite these facts little is known about the role of Kv or K2P potassium channels in the regulation of uterine contractility, and certainly nothing is known about the possible …
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
… excitable cells with a number of ion channels and signaling pathways implicated in the control of their electrical properties and ACTH secretion. However, the mechanisms involved in native corticotrophs are poorly understood partly due to the current limitations of identifying …