Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"BIP"”.
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Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
… protein catalyzes AMPylation or deAMPylation of BiP, the major ER chaperone. This work elucidates a critical role of the reversible AMPylation of BiP in maintaining the Drosophila visual system in response to constant light-induced stress. In response to extended light exposure, flies mutant for …
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Uncovering Reversible AMPylation of BiP Mediated by dFic During ER Homeostasis
… study, we identified an ER molecular chaperone BiP/GRP78 as a novel substrate for dFic-mediated AMPylation. BiP was predominantly labeled with AMP by dFic in S2 cell lysate. AMPylation of BiP decreases during ER stress but increases upon the reduction of unfolded proteins. Both dFic and BiP are …
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Uncovering Reversible AMPylation of BiP Mediated by dFic During ER Homeostasis
… study, we identified an ER molecular chaperone BiP/GRP78 as a novel substrate for dFic-mediated AMPylation. BiP was predominantly labeled with AMP by dFic in S2 cell lysate. AMPylation of BiP decreases during ER stress but increases upon the reduction of unfolded proteins. Both dFic and BiP are …
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The Role of BiP Nucleotide Exchange Factor Sil1 in Immunoglobulin Biosynthesis
<p>BiP is an essential endoplasmic reticulum resident molecular chaperone of the HSP70 family that binds exposed hydrophobic regions of unfolded proteins. Substrates bound by BiP are protected from dangerous non-specific interaction with other unfolded proteins via their aggregation prone exposed …
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Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
… and activity of Binding Immunoglobulin Protein (BiP) contributes to protein-folding homeostasis. BiP’s abundance is modulated transcriptionally by the canonical unfolded protein response (UPR). Conversely, a metazoan-specific, endoplasmic reticulum (ER)-resident, Fic domain containing protein …
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Using a multi-tier framework to increase teachers’ fidelity of BIP implementation
… with every component and strategy in student BIPs due to time constraints, number of students, or lack of training. The purpose of this study was to examine the effects of using a tiered approach to deliver performance feedback and training sessions on the fidelity of special education …
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Using a multi-tier framework to increase teachers’ fidelity of BIP implementation
… with every component and strategy in student BIPs due to time constraints, number of students, or lack of training. The purpose of this study was to examine the effects of using a tiered approach to deliver performance feedback and training sessions on the fidelity of special education …
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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis
… endoplasmicreticulum- resident Hsp70 chaperone, BiP. To date, there are 46 MSS-associated mutations that have been reported in SIL1, which occur throughout this gene and are predicted to result in a loss of SIL1’s function. The large majority of these mutations cause deletions of large fractions …
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Study of the Cellular Role of GRP78/BiP mono-ADP-ribosylation in UPR and Cancer
… that the ER-localized chaperone, GRP78/BiP, was a prime target of hARTC1. A doubly mutated hARTC1 mutant was designed, and used as a specific control for hARTC1 expression. The mutant enzyme localized to the ER, but did not catalyze GRP78/BiP ADP-ribosylation. The demonstration that …
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The role of BIP and PDI in the secretion of foreign proteins in the yeast Saccharomyces cerevisiae
As a single-celled microbial eucaryotic host for protein expression, the yeast Saccharomyces cerevisiae offers some of the advantages of bacterial systems, such as ease of fermentation, and of eucaryotic systems, such as post-translational modifications of secreted proteins. One disadvantage, …
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An investigation of the relationship between customer orientation and customer satisfaction in the Namibian public sector: A case study of the Business and Intellectual Property Authority (BIPA)
… the in the Namibian Public Sector are common and BIP A is no exception. The main objective of this study was to investigate the existence of a relationship between customer orientation and customer satisfaction at BIP A, and the specific objectives were to investigate the nature of the …
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Integração dos estresses osmótico e do RE no processo de morte celular: reguladores positivos e negativos da via de sinalização são conservados em plantas
… expressão constitutiva do chaperone molecular BiP promove uma melhor adaptação de linhagens transgenicas à seca. BiP alivia a propagação do sinal de morte celular pela modulação da expressão e atividade de componentes da via de morte celular GmNRP-A, GmNRP-B and GmNAC81.. Neste trabalho, nós …
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Identifying in-session predictors of treatment outcome for intimate partner violence (IPV): an examination of fathers for change and treatment as usual
… fathers is the “Batterer Intervention Program (BIP),” a group-based psychoeducational program with mixed empirical support. A recently developed cognitive-behavioral treatment, Fathers for Change (F4C), has demonstrated promising initial outcomes in a small randomized controlled trial comparing …
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A content analysis of battering interventions: Development of a unified framework for treating relationally violent men
… to improving battering intervention programs (BIPs) that address men’s violence. Existing data from BIPs show that relationally violent men (RVM) can be a very difficult population to treat. Meta-analyses across BIPs with differing theoretical ideologies show that these programs tend to …
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Super Low Dose Endotoxin Exacerbates Low Grade Inflammation through Modulating Cell Stress and Decreasing Cellular Homeostatic Protein Expression
… homeostatic molecules such as XBP1 and GRP78/BiP. We observed that cells challenged with SLD endotoxin have significantly reduced expression of homeostatic molecules XBP1 and BiP. Mechanistically, we observed that SLD-LPS increases phosphorylated HCK expression in TM treated cells. …
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Stress-signal recognition in the unfolded protein response
… it has been proposed that the Hsp70 chaperone BiP, a major component of the ER protein folding machinery, couples IRE1α signalling to the folding state of the compartment. This is supported by data showing that the luminal J-domain co-chaperone ERdj4 promotes the formation of a complex between …
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Solving hybrid decision-control problems through conflict-directed branch & bound
… (HDCPs) are encoded in a binary integer program (BIP). These BIPs are solved using Branch and Bound (B&B) techniques. Two problems arise with this approach. First, binary arithmetic is not a natural representation for expressing complex logical choices. Propositional and higher order logics offer …
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Studies to Characterize the Requirements for the Binding and Release of ERdj3, a Mammalian ER DnaJ Homolog, from Substrates
… immunoglobulin heavy chains (HC) along with the BiP chaperone complex in the endoplasmic reticulum of mammalian cells. Here we demonstrate that ERdj3 binds directly to two unfolded substrates: immunoglobulin γHC and denatured firefly luciferase. Using mutagenesis studies on ERdj3 in both <em>in …
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BIOINFORMATIC ANALYSIS OF A MAMMALIAN BIP GENE FOR INSERTION INTO GREEN ALGAE AND COMPARISON OF ITS POSSIBLE EFFECTS ON THE SYNTHESIS OF A MAMMALIAN ANTIBODY
… protein 78 (grp 78), also known as BiP. The selected homologous proteins originate from organisms of infinitely diverse genera. Comparisons of protein sequence yielded the first clues of a common ancestry among these proteins. Furthermore, protein molecular weights, isoelectric …
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Proton Computed Tomography: Matrix Data Generation Through General Purpose Graphics Processing Unit Reconstruction
… versions called block-iterative-projection (BIP) methods and string-averaging-projection (SAP) methods. General purpose graphics processing units (GPGPUs) have hundreds of stream processors for massively parallel calculations. A GPGPU cluster is a set of nodes, with each node containing a set …
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