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Showing 1 to 20 of 33 for “"BIO/19 Microbiologia"”.
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Interazioni tra Glicoproteine che mediano la penetrazione del Virus Herpes Simplex nella cellula e disegno razionale di Peptidi Inibitori
… cross-talk to each other we searched for biochemical defined complexes in infected and transfected cells, and in virions. We report that gD formed complexes with gB in absence of gH/gL, and with gH/gL in absence of gB. Complexes with similar composition were formed in infected and …
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Interazioni tra le glicoproteine D, B, H ed L critiche per la fusione indotta dal virus Herpes simplex
… strep-tag. The gB sequence between aa residues 219-360 was identified as putative region of interaction with gH or critical to the interaction.
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Molecular basis oh herpes simplex virus entry into the cell and retargeting of the viral tropism for the design of oncolytic herpesviruses
… of ONE-STrEP-tag system by IBA. With respect to biological function, the purified heterodimer is capable: • of reacting to antibodies that recognize conformation dependent epitopes and neutralize virion infectivity; • of binding a variety cells at cell surface. No doubt, the availability of …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
The search for new targets and antiviral agents is continuously growing, especially for agents with broad-spectrum activity. In fact, even though vaccines are the elective way to limit diseases and possibly eradicate pathogens, they are not always effective, particularly in people with compromised …
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From Fossils to Function: Exploring the Evolutionary And Functional Diversity Of HERV Envelope Proteins Across Primate Lineages
… among retroviral elements that impacts host biology.
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
Introduction Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative bacteria and are emerging as an attractive vaccine platform. The exploitation of OMVs in cancer immunotherapy was tested by decorating them with cancer epitopes and by following their capacity to …
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Bacterial lipoproteins: sorting mechanisms and biotechnological applications
The mechanism responsible for lipoprotein sorting is conserved among bacterial species. However, the final destination of lipoproteins may vary among species. In some species lipoproteins are surface-exposed while in others they are associated to the outer membrane but facing the periplasm. To …
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Acquisition and Exclusion of Pathogenicity Island 1 (PAPI-1) in Pseudomonas Aeruginosa
… virulence genes and a major regulator of biofilm formation and antibiotic-resistant traits and was found to be horizontally transferable into strains lacking it. The conjugation of PAPI-1 island transfer is mediated by type IV pilus, which is encoded by ten genes located in PAPI-1. …
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
… genome. The human genome assembly GRCh 37/hg19 was analyzed with RetroTector software and a total of 3290 HERV proviral sequences were identified. The complex genetic structure of the 3290 proviruses was resolved through a multi-step classification procedure that involved a novel type of …
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A computational approach for identification and development of novel inhibitors targeting viral polymerases
… with more recent approaches including structural biology and computational modeling can work efficiently to hasten discovery of active molecules. The ability to design drugs interfering with the progression of infection of virus comes with i)the knowledge of pathological, cellular and molecular …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
The Human Immunodeficiency Virus (HIV) integrates its genome into the host DNA and persists for the lifetime of the infected cell. Even in the presence of an efficacious Highly Active Anti-Retroviral Therapy (HAART) treatment, a pool of latently infected cells persists and reactivates to produce …
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Biochemical, computer, and spectroscopic techniques applied to the study of prions and of combinations of antineoplastic drugs
… activity in vitro (Pivetta et al., J Inorg Biochem. 2011 and 2012). Binary combinations comprising CDDP and Cu(II) complexes revealed (Part I, Chapter I) a strong synergistic cytotoxic effect against leukemia cell lines (Pivetta et al., Talanta 2013). The synergistic effect was confirmed in …
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
… of HERVs to significantly interfere in human biology, in both physiological and pathological scenarios. However, despite a few cases such as the one of Syncityn--‐1, the HERV physiological role an their involvement in the development of diseases such as cancer, autoimmune diseases, neuronal …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… of tissue-resident T-cells in response to a dysbiotic composition of the gut microbiota. In particular, the pathogenesis of CD has been linked to a significant enrichment of pathogenic IFNγ-producing Th17 cells with a concomitant selective and significant enrichment of adherent-invasive E. coli …
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