Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"BIO/18 Genetica"”.
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Insulin and TOR pathways regulate cellular and organismal growth through the myc oncogene in Drosophila
… and translation of RNAs implicated in ribosome biogenesis (Vanhaesebroeck et al. 2001). Moreover several lines of evidence implicate this pathway as a causal factor in cancer (Sale, 2008; Zeng and Yee 2007; Hursting et al., 2007; Chan et al., 2008). With regards to Myc, studies in cell culture …
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Morphogenesis of follicular epithelium in Drosophila melanogaster: function of von Hippel-Lindau tumour suppressor gene
… The Drosophila follicular epithelium is a genetically tractable model to understand these mechanisms in vivo. Therefore, to examine whether d-VHL has a role in epithelial morphogenesis and maintenance, I performed genetic and molecular analyses by using in vivo and in vitro approaches. From …
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Genetica molecolare dell'autismo: studi di associazione ed analisi di geni candidati
… the AUTS1 and AUTS5 regions, respectively, and 188 gender-matched controls. Association and CNV analysis implicated several new genes, including IMMP2L and DOCK4 on chromosome 7 and ZNF533 and NOSTRIN on the chromosome 2. Particularly, my contribution to this project focused on the …
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
The biological complexity of NGF action is achieved by binding two distinct Neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
… the addition of either agonist or antagonist (17,18,19). We designed a HeLa cell line (PRL-HeLa), engineered with a chromosomeintegrated reporter gene array (PRL-array) containing multicopy hormone response-binding elements for ERalpha that are derived from the physiological enhancer/promoter …
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PLANT TOLERANCE TO DROUGHT: MODULATION OF TRANSCRIPTION FACTORS
… of water are used in agriculture, and abiotic stresses, especially drought and increased salinity, are primary causes of crop loss worldwide. Various approaches may be adopted to consume less water in agriculture, one of them being the development of plants that use less water yet …
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Overcoming radioresistance by targeting p21 in cancer
… response, proposing its potential as a biomarker and therapeutic target to overcome radioresistance in cancer.
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… this mechanism have been outlined by genetic and biochemical means in budding and fission yeasts, thanks to their genetic versatility and experimental tractability. The current model predicts that activation of the first checkpoint kinase in the cascade is not due to the DNA damage itself, but it …
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THE ARABIDOPSIS THALIANA ABC TRANSPORTERS TAP1, NAP8 AND ATH12 EXTRUDE PEPTIDES FROM CHLOROPLASTS AND ARE LINKED TO CHLOROPLAST PROTEIN HOMEOSTASIS MAINTENANCE.
… ai cianobatteri tramite un antico evento endosimbiontico, in maniera simile a quanto accaduto per il mitocondrio. Come vestigi delle sue origini, il cloroplasto possiede un genoma che ancora esprime poche proteine plastidiali. Come diretta conseguenza, il proteoma del cloroplasto è un mosaico di …
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Ethical, Legal and Social/Societal Implications (ELSI) of Recall-by-Genotype (RbG) approaches in the Cooperative Health Research in South Tyrol (CHRIS) study on genetic risk factors of Parkinson’s disease (PD)
… policies employed in different research and biobanking con-texts. Then, a secondary analysis of interviews and surveys from a mixed-methods study with CHRIS RbG participants from the RbG pilot study (RbG1) followed. Alongside the second follow-up RbG study (RbG2) study, we then designed a …
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THE MESENCHYMAL IDENTITY OF NF-YA LONG ISOFORM: FROM VERTEBRATE EVOLUTION TO CANCER
… con elevato NF-YARatio. Tramite un’analisi filogenetica nei vertebrati ho scoperto pattern distinti nello splicing di NF-YA, con NF-YAl prevalentemente espresso in campioni differenziati/associati al mesoderma. Ho evidenziato un’isoforma esclusiva negli uccelli, NF-YAg, e un retrogene, NF-YAr, …
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Spatial representation from birth to old age: Insights from comparative neurobiology and behavioral genomics.
Finding one’s way back to a safe refuge or recalling the best place to find food is essential to all animals including human beings. We engage in future actions based on past events. So how does our brain compute such important cognitive tasks? Is it an innate ability we have from birth that is …
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Role of chromatin condensates in tuning nuclear mechano-sensing in Kabuki Syndrome
The human genome is characterized by an extent of functions that act further than its genetic role. Indeed, the genome can also affect cellular processes by nongenetic means through its physical and structural properties, specifically by exerting mechanical forces that shape nuclear morphology and …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… the demand of heme production, the delayed heme biosynthesis leads to the accumulation of porphyrins ’precursors, involved in neurotoxicity, and hyperactivity of ALAS1, the first rate-limiting enzyme of the heme pathway. AIP clinical manifestations presents in 0.5-1% of HMBS-mutation carriers and …
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Translational control mechanisms in the p53 response network
The sequence-specific transcription factor p53 is considered a master gene of cellular responses to homeostasis changes. It is also a prominent tumor suppressor gene with the title of “guardian of the genome”. The increasing number of transcriptome analyses in cell lines treated with different …
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INSIGHTS INTO THE GENETIC DIVERSITY OF ASIMINA TRILOBA: A STUDY USING GENOME ASSEMBLY AND POPULATION GENETICS
… genome by assembling a draft genome using PacBio's Sequel II long reads and polishing with Illumina short reads. We first used a genotype-by-sequencing (GBS) to genotype 124 individuals from 28 sites across the state of Virginia to produce a set of single nucleotide polymorphisms (SNPs). We …
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FUNCTIONAL CHARACTERIZATION OF VPS13 DURING SEXUAL AND APOMICTIC PLANT REPRODUCTION: THE MISSING GENE FOR PLANT BREEDING?
Nei prossimi anni, la produzione agroalimentare dovrà aumentare per assicurare cibo alla popolazione mondiale in continua crescita. La generazione di ibridi è uno dei metodi per incrementare la produttività, poiché questi si contraddistinguono per le migliori caratteristiche rispetto alle linee …
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