Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"BIO/14 Farmacologia"”.
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Development of screening assays to test novel integrin antagonists in allergic inflammation
Aim of the research: to develop a prototype of homogeneous high-throughput screening (HTS) for identification of novel integrin antagonists for the treatment of ocular allergy and to better understand the mechanisms of action of integrin-mediated levocabastine antiallergic action. Results: This …
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
… effect of the NK1 receptor antagonist SSR140333 on: 1) acute model of intestinal inflammation; 2) reactivation of DNBS-induced colitis in rats. Methods: Acute colitis was induced in male SD rats by intrarectal administration of DNBS (15 mg/rat in 50% ethanol). Reactivation of colitis was …
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Isotiocianati come potenziali farmaci antileucemici: identificazione in vitro ed ex vivo del profilo molecolare e cellulare
… nell’attivazione/detossificazione di xenobiotici e ad effetti citostatici e citossici, osservati su numerose linee cellulari. Un isotiocianato particolarmente promettente è il sulforafane (SFN). La ricerca condotta durante il periodo di dottorato si è, quindi, focalizzata …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
The repressor element 1-silencing transcription factor (REST) was first identified as a protein that binds to a 21-bp DNA sequence element (known as repressor element 1 (RE1)) resulting in transcriptional repression of the neural-specific genes [Chong et al., 1995; Schoenherr and Anderson, 1995]. …
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Inibizione selettiva del gene MYCN mediante PNA (acidi peptido nucleici) anti-gene nel rabdomiosarcoma umano
MYCN oncogene amplification/expression is a feature of many childhood tumors, and some adult tumors, and it is associated with poor prognosis. While MYC expression is ubiquitary, MYCN has a restricted expression after birth and it is an ideal target for an effective therapy. PNAs belong to the …
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Transcriptional regulation of human mu-opioid receptor gene: functional characterization of activating and inhibitory transcription factors
The organization of the nervous and immune systems is characterized by obvious differences and striking parallels. Both systems need to relay information across very short and very long distances. The nervous system communicates over both long and short ranges primarily by means of more or less …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
Nandrolone and other anabolic androgenic steroids (AAS) at elevated concentration can alter the expression and function of neurotransmitter systems and contribute to neuronal cell death. This effect can explain the behavioural changes, drug dependence and neuro degeneration observed in steroid …
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Indagine sul coinvolgimento del sistema neuropeptidergico nocicettina/recettore NOP a carico della trasmissione nocicettiva
… della nocicettina e degli analoghi sintetici [Arg14, Lys15]N/OFQ e UFP-101 di modificare la soglia nocicettiva nel ratto, rilevata con il test del tail-flick, a seguito di somministrazione diretta nello spazio subaracnoideo, in confronto con la nocicettina stessa. La somministrazione intratecale …
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LONG-LASTING MOLECULAR ALTERATIONS FOLLOWING EARLY LIFE STRESS IN RATS: ROLE OF GUT MICROBIOTA AND INFLAMMATION
… manifested, is still needed. Moreover, among the biological systems involved, the gut microbiota has recently been proposed to act at the interplay between the stress response system, brain functionality and inflammatory processes, through the gut-brain-immune axis communication. To better …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
… integrating demographic, clinical, lifestyle and biological characteristics. Novel analytical approaches that allow to leverage pleiotropy to improve the yield of existing genome-wide summary statistics might also be of help to identify novel potential drug targets. In this thesis, we focus on the …
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50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs as a possible behavioral marker of the affective properties of dopamine-replacing therapy in Parkinson's disease
The current leading therapeutic strategy used to manage Parkinson’s disease (PD) is the so-called dopamine replacement therapy (DRT). However, the prolonged use of DRT is associated with the onset of both motor and non-motor complications. The latter include alterations in the emotional state and …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
Anorexia nervosa (AN) is a life-threatening eating disorder in which a disturbed perception of body image leads to severe caloric restriction often accompanied by other maladaptive behaviours aimed at further reducing body weight, such as excessive physical activity or purging methods. The …
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