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Showing 1 to 20 of 125 for “"BIO/11 Biologia molecolare"”.
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Identification of surface protein complexes of Streptococcus pyogenes through protein microarray technology
… each purified protein was then labeled with biotin, hybridized to the microarray and interactions were detected with Cy3-labelled streptavidin. Only reciprocal interactions, i. e. binding of the same two interactors irrespective of which of the two partners is in solid-phase or in solution, …
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Mechanisms of cell senescence: p21 and DNA damage response in aging and longevity
Theory of aging postulates that aging is a remodeling process where the body of survivors progressively adapts to internal and external damaging agents they are exposed to during several decades. Thus , stress response and adaptation mechanisms play a fundamental role in the aging process where the …
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Identification of Drosophila heart-specific Cis-Regulatory Modules under Hox control
… regions of these target genes we developed a new bioinformatic approach where prediction is based on pattern matching and ordered statistics. We first retrieved Conserved Noncoding Sequences from the alignment between the D.melanogaster and D.pseudobscura genomes. We scored for combinations of …
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Localizzazione della topoisomerasi IB sui telomeri di S. cerevisiae e ruolo della sua attività catalitica sulle modificazioni istoniche
… DNA Topoisomerasi, influenza molti processi biologici, quali la trascrizione, la replicazione, la ricombinazione ed il rimodellamento della cromatina. La DNA Topoisomerasi IB eucariotica, (Top1), è un enzima efficiente nella rimozione dei superavvolgimenti del DNA in vitro e la sua principale …
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Analisi del circuito di regolazione responsabile del controllo trascrizionale dei geni Heat-Shock in Helicobacter pylori
… stata confermata sperimentalmente la predizione bioinformatica della sua associazione con la membrana interna. La citotossicità e l’insolubilità di HrcA in E. coli sono state alleviate inducendone l’espressione a 42°C. Saggi in vitro con le proteine ricombinanti purificate, HspR e HrcA, hanno …
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THE SUBTLE BIOFILM REGULATION IN ESCHERICHIA COLI: CSGD AND THE YDDV-DOS OPERON
… and EAL proteins, on their modulation in E. coli biofilm formation in response to environmental signals and on regulation of curli fibers, cellulose and poly-N-acetylglucosamine (PNAG), the most important biofilm determinants in E. coli. E. coli is an Enterobacterium, normally living inside the …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… marker for predicting distant metastasis and biochemical recurrence and its expression in radical prostatectomy biopsies concurred with diagnostic biopsies (concordance 87.6%). Using the human cell lines, LNCaP (androgen-sensitive) and DU145 (androgen-insensitive), we found that NCAM1, but not …
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INVESTIGATING GENOME PROTECTION AT G-QUADRUPLEXES: STRUCTURAL-FUNCTIONAL ANALYSIS OF S. CEREVISIAE DOMESTICATED TRANSPOSASE VID22
… implicate nella modulazione di numerosi processi biologici, inclusi la trascrizione e la replicazione. Di conseguenza, la perturbazione dell'omeostasi delle G-tetradi è associata ad alterazioni nell'espressione genica, a stress replicativo, a rotture del DNA e, in ultima analisi, a un aumento …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
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UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
YAP and TAZ are transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced …
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A MOLECULAR UNDERSTANDING OF ANEUPLOID CELL CLEARANCE
Chromosome segregation errors can lead to aneuploidy, an abnormal chromosome number associated with cancer and genome instability. My Ph.D. research focused on understanding the interplay between aneuploid cells and the immune system. By utilising mass spectrometry and the Surfaceome database, I …
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DEFINING THE ROLE OF THE PCGF3-CONTAINING POLYCOMB REPRESSIVE COMPLEX 1 IN SYNOVIAL SARCOMA
… affinity of the fusion oncoprotein for H2AK119ub, the histone modification deposited by Polycomb Repressive Complex 1 (PRC1). However, the precise molecular mechanisms underlying SS18-SSX transformation remain unclear. Given SS's disruption of epigenetic regulators SWI/SNF and Polycomb …
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