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Showing 1 to 7 of 7 for “"BH3-only Proteins"”.
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… of intrinsic apoptosis are the Bcl-2 family proteins. While some members of this family are pro-survival, the Bcl-2 homology-3 domain (BH3)-only proteins are pro-apoptotic. Since cooperation of various BH3-only proteins is often necessary to induce apoptosis, we hypothesized that multiple …
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Exploring the Activation Landscape of Pro-Apoptotic BAK Through the Discovery of Human BH3-Only and Non-Native Peptide Binders
… Previous work has shown that binding of certain BH3-only proteins such as truncated BID (tBID), BIM, and PUMA to pro-apoptotic BAK leads to mitochondrial outer membrane permeabilization (MOMP), release of cytochrome c, and ultimately cell death. The BH3 binding event leads to a series of …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… cancer, with mutations in KRAS and BRAF commonly occurring in cancers of the pancreas, skin, and colon, among others. Indeed, BRAF and MEK1/2 inhibitors are approved for the treatment of BRAF-mutant malignant melanoma and are improving patient outcomes. However, the development of acquired …
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The Role of Sphingosine Kinase 2 in Cell Growth and Apoptosis
… a 9 amino acid motif similar to that present in BH3-only proteins. Studies showed that the BH3-only domain, catalytic activity, endoplasmic reticulum (ER) stress, and uptake of calcium by the mitochondria may all contribute to the apoptotic effects of overexpressed SphK2 in NIH 3T3 cells. Further …
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Der C-Terminus des antiapoptotischen Bcl-2 Familienmitgliedes A1 reguliert Stabilität und Funktionalität des Proteins
… wies im Vergleich zum Wildtyp eine höhere Proteinstabilität auf. Die Fusion der letzten 35 Aminosäuren von A1 an eine enzymatisch inaktive Form von Caspase 3 führte zu einem sehr instabilen chimären Protein. Somit scheint der C-Terminus von A1 sowohl notwendig als auch hinreichend für die …
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Delineating the Steps of BAX Pore Activation
… A third class of the BCL2 family, the prodeath BH3-only proteins, act as sentinels of cell stress and exert their influences by occupying antiapoptotic BCL2 members and/or activating BAX/BAK. Cell-free reconstitution assays have revealed that BAX/BAK undergo significant conformational changes to …
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Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
… gezeigt, dass nach induzierter Expression des BH3-only Proteins BimS eine Infektion mit Toxoplasma die Apoptose sehr effektiv hemmte und dabei die Aktivitäten der Caspasen 9, -3/7, und 8 dosisabhängig reduzierte. Nach Hemmung der Feedback-Aktivierung des mitochondrialen Apoptoseweges durch …