Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"BH3-only Protein"”.
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
Human Noxa, a BH3-only member of the Bcl-2 family of apoptosis regulators, was shown to have both pro-apoptotic and pro-survival functions in human hematological malignancies. Noxa protein is not expressed in unstimulated or naïve human T cells but is induced in CD8+ T cells upon receptor …
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Vesicular stomatitis virus induced apoptosis occurs by a mechanism involving the activation of pro-apoptotic Bcl-2 proteins Bak and Bid and the inactivation of anti-apoptotic Bcl-2 proteins Bcl-XL and Mcl-1
… I address the question of what role Bcl-2 family proteins play in apoptosis induced by vesicular stomatitis virus (VSV) with wild-type (wt) M protein (rWT virus). My results demonstrate that of the two major proapoptotic multidomain proteins Bak and Bax, Bak is more important for the induction of …
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The regulation of programmed and pathological cell death in C. elegans
… is evolutionarily conserved in humans. The BH3-only protein EGL-1 is transcriptionally upregulated in cells fated to undergo programmed cell death, and EGL-1 blocks cell-death inhibition by the cell-death regulator CED-9, a Bcl-2 family member. The binding of EGL- 1 to CED-9 releases the …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… inactivation of a pro-survival mitogen activated protein kinase kinase (MEK)1/2/ extracellular signal regulated-kinase (ERK)1/2 cascade which functions in healthy CGNs to promote the degradation of the pro-apoptotic Bcl-2 homology-3 domain (BH3)-only protein Bim while also repressing a …
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Insights into p53-Dependent Apoptotic Signaling and Cell Fate vis-a-vis Functional Cooperation among BCL-xL, Cytoplasmic p53, and PUMA
… PUMA (p53 upregulated modulator of apoptosis), a BH3‑only protein that binds and inhibits the anti‑apoptotic BCL‑2 repertoire, including BCL‑xL. Structural investigations of PUMA and the BCL‑xL×PUMA BH3 domain complex by X‑ray crystallography and nuclear magnetic resonance (NMR) spectroscopy …
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Biochemische und molekularbiologische Charakterisierung von Spike, einem neuen BH3-Domänen Protein
… conserved cDNA that codes for a novel BH3-only protein of 219 amino acid residues which was named Spike, for Small protein with inherent killing effect. Spike was then in the course of my PhD thesis extensively characterised, molecularly and biochemically. In summary, upon …
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… growth factor(bFGF), as well as intrinsic protein regulate growth, proliferation and differentiation. Therefore, in culture system, addition of both bFGF and EGF is critical to maintain and expand NECs. The withdrawal of the seGFs induced apoptosis through intrinsic mitochondrial pathway in …
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DRE-1/FBXO11, a Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
… both the CED-3 caspase and CED-4/Apaf-1 adaptor proteins, the BH3-only protein EGL-1 is dispensable. Thus, other gene(s) substitute for egl-1's role as a regulator of caspase activation in this cell, and we set out to identify the relevant gene or genes. A screen for mutants in which the …
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Biochemische und molekularbiologische Charakterisierung von CybL und Saip, zweier dominant apoptoseinduzierender Gene
… und um Saip (Small apoptosis inducing protein) einem Protein, das am endoplasmatischen Retikulum (ER) lokalisiert ist. Bisher war bekannt, daß die Atmungskettenkomplexe I und III bei der Fas-Ligand und der Ceramid-vermittelten Apoptose beteiligt sind. Über einen Zusammenhang von Komplex …
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The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1
… Type 1 (NF1) is one of the most commonly inherited autosomal dominant human genetic disorders, with an incidence of approximately 1 in 3000~3500 individuals worldwide. NF1 is caused by loss-of-function mutations in the NF1 gene encoding neurofibromin, a GTPase-activating protein that …
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Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
… in dieser Arbeit gezeigte Modulation der Bcl-2-Proteine eine wichtige Rolle spielen. Allerdings kann eine zusätzliche Inhibierung durch Verhinderung der Apoptosombildung nicht komplett ausgeschlossen werden.Wie T. gondii die Cytochrom c-Freisetzung aus den Mitochondrien des intrinsischen …