Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"BH3-mimetic"”.
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… resistance to many therapeutics including the BH3-mimetic agents ABT-199 and ABT-263. The anti-malarial, dihydroartemisinin (DHA) translationally represses MCL-1 and synergizes with BH3-mimetics. To explore how DHA represses MCL-1, a genome-wide CRISPR screen identified that loss of genes in …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… increases the abundance of pro-apoptotic BH3-only proteins such as BIM and BMF. However, despite this, responses to ERK1/2 pathway inhibitors are typically cytostatic, reflecting the residual activity of pro-survival BCL2 proteins. In this thesis, we determined that melanoma cells had a …
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Design of selective peptide inhibitors of anti-apoptotic Bfl-1 using experimental screening, structure-based design, and data-driven modeling
… family proteins bind to short, pro-apoptotic BH3 motifs to support cellular survival. Overexpression of BfI-1 has been shown to promote cancer cell survival and the development of chemoresistance. Prior work suggests that selective inhibition of Bfl-1 can induce cell death in Bfl-1 …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… response to MEK1/2 inhibitors when combined with BH3-mimetics such as ABT263, small molecules that inhibit pro-survival proteins of the apoptotic pathway. The RSK1/2 protein kinases, immediate downstream targets of ERK1/2, have also been implicated in the destabilisation of BIMEL. Specifically …
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Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
<p>Gastrointestinal stromal tumors (GISTs) are oncogene-addicted cancers driven by activating mutations in the genes encoding receptor tyrosine kinases KIT and PDGFR-α. Imatinib mesylate, a specific inhibitor of KIT and PDGFR-α signaling, delays progression of GIST, but is incapable of achieving …