Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"BH3 profiling"”.
-
Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
… Our biomarker studies demonstrate that both BH3 profiling and the expression profiling of BCL-2 proteins may serve as predictive biomarkers for the efficacy of ABT-199. Despite the initial success, we find that MCL-1 protein renders cancer cells resistant to ABT-199. Next we investigated …
-
Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… suggesting an altered interactome at relapse. By BH3 profiling, VEN relapsed CLL did not completely lose dependence on BCL2 (BAD sensitivity), yet denoted co-dependence on alternative anti-apoptotic proteins, mainly BCL-XL (XXA1_Y4eK sensitivity). Moreover, VEN was unable to induce significant BAK …