Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"BET proteins"”.
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The role of BET proteins in castration-resistant prostate cancer dissemination
… progression, the Bromodomain and ExtraTerminal (BET – BRD2, BRD3 and BRD4) family of proteins, to test the hypothesis that each BET family member regulates EMT and underlying characteristics such as cell motility and invasiveness. We systematically manipulated the BET proteins and found that BRD4 …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… this experiment, it emerged that inhibition of BET (bromodomain-extra-terminal domain) proteins robustly synergized with ASO antiC in reducing ALT cells proliferation. Moreover, the inhibition of these epigenetic readers led to apoptosis activation only in ALT cells, suggesting a TMM-specific …
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Molecular regulation of BRD3 in forward programming of Megakaryocytes
… within the bromodomain and extra terminal (BET) family, specialised in recognising and binding to acetylated lysine residues. In this project, I studied the functions of BRD3 during megakaryopoiesis, the process that leads to platelet formation. Because platelets do not have nucleus, …
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The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… increasing their sensitivity to epigenetic BET inhibitors. This project aims to explore the role of ARID1A loss in driving metastatic ER+ breast cancer, using the most clinically relevant mouse intraductal xenografting model. In vivo investigations demonstrated that the loss of ARID1A leads …
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Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma
… rates remain around 60% for localized and between 5-30% for metastatic disease. OS has a high propensity for early hematogenous and recurrence, indicating a critical need for novel treatment options. Genomic analysis from the Pediatric Cancer Precision Genomics Program at our institution …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… antibody-mediated rejection in transplantation. BET proteins are a family of histone modification ‘readers’ that bind acetylated lysine residues within histones and function as a scaffold for the assembly of complexes that regulate gene transcription. Bromodomain inhibitors (I-BET) selectively …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… protein 4 (BRD4), one of the BET (bromodomain and extra terminal) family proteins, represents a class of epigenetic readers that regulate gene transcription by binding to acetylated lysine of histone and non-histone proteins via their bromodomains (BDs). This interaction either …