Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"BET protein"”.
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A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains
… tools can be used to investigate the function of proteins and their importance to biological processes and disease. This approach has many advantages over classical genetic tools, but requires compounds with high selectivity for their targets. When single-target selectivity cannot be achieved …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… this experiment, it emerged that inhibition of BET (bromodomain-extra-terminal domain) proteins robustly synergized with ASO antiC in reducing ALT cells proliferation. Moreover, the inhibition of these epigenetic readers led to apoptosis activation only in ALT cells, suggesting a TMM-specific …
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Cell Memory and Fate in Human Development
… for the bromodomain and extra-terminal domain (BET) family of epigenetic readers, which facilitate transcription through interactions with acetylated residues of histones and other proteins and are thought to promote tumor formation in the context of cancer. I showed that inhibition of BET …