Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"BET inhibitors"”.
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The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… increasing their sensitivity to epigenetic BET inhibitors. This project aims to explore the role of ARID1A loss in driving metastatic ER+ breast cancer, using the most clinically relevant mouse intraductal xenografting model. In vivo investigations demonstrated that the loss of ARID1A leads …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… protein 4 (BRD4), one of the BET (bromodomain and extra terminal) family proteins, represents a class of epigenetic readers that regulate gene transcription by binding to acetylated lysine of histone and non-histone proteins via their bromodomains (BDs). This interaction either …
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Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma
… rates remain around 60% for localized and between 5-30% for metastatic disease. OS has a high propensity for early hematogenous and recurrence, indicating a critical need for novel treatment options. Genomic analysis from the Pediatric Cancer Precision Genomics Program at our institution …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… this experiment, it emerged that inhibition of BET (bromodomain-extra-terminal domain) proteins robustly synergized with ASO antiC in reducing ALT cells proliferation. Moreover, the inhibition of these epigenetic readers led to apoptosis activation only in ALT cells, suggesting a TMM-specific …
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Identifying and Targeting Adaptive Changes to Bet Inhibition In Ovarian Cancer
… using Bromodomain and Extra-Terminal Domain (BET) inhibitors in a mechanism driven fashion to maximize anti-tumor activity, and to determine the efficacy of BET inhibitor combinations in pre-clinical ovarian cancer mouse models.</p> <p><strong>Experimental Design: </strong>We used a novel, …