Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 324 for “"BET"”.
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Strukturbestimmung des Birkenpollenallergens Bet v 4
Bet v 4 ist ein minores Allergen aus Birkenpollen (Betula verrucosa). Es gehört zur Familie der Polcalcine, kleinen Calcium bindenden Allergenen mit je 2 EF-Hand Strukturmotiven, die in einer Vielzahl höherer Pflanzen gefunden werden. Es wurden effektive Strategien zur Präparation von rekombinantem …
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THE ROLE OF T-BET IN LUNG INFECTION
The T-box transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. In this thesis, a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral …
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Identifying and Targeting Adaptive Changes to Bet Inhibition In Ovarian Cancer
… using Bromodomain and Extra-Terminal Domain (BET) inhibitors in a mechanism driven fashion to maximize anti-tumor activity, and to determine the efficacy of BET inhibitor combinations in pre-clinical ovarian cancer mouse models.</p> <p><strong>Experimental Design: </strong>We used a novel, …
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Bet- hedging reproduction strategies in the massive Caribbean coral Favia fragum
Bet- hedging has long been recognised as an adaptive mechanism in unpredictable environments, yet is often overlooked as an evolutionary strategy in corals to adapt to environmental conditions associated with climate change. Most environments vary spatially and temporally over the lifespan of …
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The role of BET proteins in castration-resistant prostate cancer dissemination
… progression, the Bromodomain and ExtraTerminal (BET – BRD2, BRD3 and BRD4) family of proteins, to test the hypothesis that each BET family member regulates EMT and underlying characteristics such as cell motility and invasiveness. We systematically manipulated the BET proteins and found that BRD4 …
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BETTING ON ALTERNATIVES: TARGETING TELOMERIC DILNCRNA AND BET PROTEINS IN ALT CANCER
… this experiment, it emerged that inhibition of BET (bromodomain-extra-terminal domain) proteins robustly synergized with ASO antiC in reducing ALT cells proliferation. Moreover, the inhibition of these epigenetic readers led to apoptosis activation only in ALT cells, suggesting a TMM-specific …
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T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection
… into the role of the Th1 transcription factor, T-bet, during murine T. cruzi infection revealed that T-bet is required for resistance. Contrary to our expectations, T-bet was not required for the development of Th1 immunity during infection, as T-bet-deficient mice still developed …
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A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains
… allele-specific chemical genetic work is the BET family of bromodomains – 8 closely related, and structurally conserved, epigenetic acetyl-lysine reader domains that so far has defied single-bromodomain inhibition. The Alessio Ciulli lab has previously designed a proof-of-concept ‘bump-&-hole’ …
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Value Driven: An Analysis of Attitudes and Values Via BET Programming Past and Present
… towards the programming disseminated on the BET network past and present (pre-Viacom/post-Viacom). The mass media company Viacom acquired BET from African American founder Robert L. Johnson in 1980. BET under Johnson took pride in its ability to provide sophisticated, value-driven, and …
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Numbers And Neighborhoods: Seeking And Selling The American Dream In Detroit One Bet At A Time
<p>The study of numbers gambling in Detroit offers an important perspective on the concept and performance of community cohesion within the urban fabric of the United States. Research is limited concerning the role numbers gambling has played in community cohesion. This dissertation expands the …
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T-Bet Expressing B Cells With Distinct Residency And Functional Characteristics Give Rise To Plasma Cells
An increasing body of work shows that T-bet+ B cells play important roles in immune responses to infections a well as in autoimmune diseases. These studies investigate the kinetics, tissue distribution, and functions of T-bet+ B cells in a murine influenza infection model. Both T-bet+ and T-bet- …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
Mice lacking the transcription factor T-bet in the innate immune system (Tbx21-/- x Rag2-/- Ulcerative Colitis, or TRUC) develop microbiota-dependent inflammatory bowel disease (IBD). The innate immune mechanisms responsible for causing disease are still to be resolved, yet potentially offer novel …
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"I bet you wished you'd picked a different group": an ethnographical study of practice development unit accreditation.
… of implementing changes; ii) to erode divides between employees that are based on professional and hierarchical identities; iii) to create succession plans in order to maintain effective leadership; iv) those initiating change should understand the notion of functional conflict. Further …
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Life history strategies in variable environments: Demography, delayed germination and bet-hedging in a desert annual Plantago
… A pattern of delayed germination consistent with bet-hedging as an adaptation to temporal variability in reproductive success arose in the field, in part, because frequencies of wet and dry germination conditions differed among populations. Phenotypic plasticity in germination response for seeds …
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Studies in Framework Science Metal-organic Framework Composites BET Theory and Adsorption Reticular Chemistry and DNA Frameworks
… outlines the triangular relationship between frameworks, surfaces, and self-assembly. As such, it is organised in three distinct projects each corresponding to one of the three poles of this triangle. Frameworks | In this project, the chemistry of metal-organic framework (MOF) …
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Struktur, Funktion und Allergenität Bet v 1-homologer Proteine: Das Allergen Gly m 4 und das Enzym Norcoclaurin-Synthase
In Nord- und Mitteleuropa wird ein beträchtlicher Teil der Pollen- und Nahrungsmittelallergien bei Erwachsenen durch allergene Proteine aus der Bet v 1-Familie ausgelöst, die nach dem Hauptbirkenpollenallergen benannt ist. Die Bet v 1-Familie wird in die Klasse 10 der pathogenesis-related proteins …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to …
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Strukturbestimmung von Birkenpollenallergenen und birkenpollenassoziierten Nahrungsmittelallergenen mit NMR-Spektroskopie
Das 17,4kDa schwere Hauptbirkenpollenallergen Bet v 1 ist bei mehr als 90% der Birkenpollenallergiker für die Bindung der IgE-Antikörper verantwortlich, und IgE-Kreuzreaktionen mit verwandten Proteinen wie Pru av 1 (früher Pru a 1) aus Kirschen, Gly m 4 (ursprünglich SAM22) aus Sojabohnen und Api g …
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Die physiologische und immunologische Rolle von PR-10 Allergenen
… von Pollen– und Nahrungsmittelallergenen der Bet v 1-Superfamilie ausgelöst. Die Bet v 1-homologen Vertreter werden meist in Form von multiplen, beinahe identischen Isoformen durch umweltbedingten Stress induziert und in die pathogenesis related 10 Proteinfamilie (PR-10) untergeordnet. Trotz …
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Combustion of aerosolized spherical aluminum powders and flakes in air
… determined using the Brunauer-Emmett-Teller (BET) method and respective "BET diameters". It is observed that the rates of pressure rise and rates of flame propagation were higher for aluminum powders with BET diameters of about 2 to 5 um compared to aluminum flakes for which the BET diameters …
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