Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"BENZTROPINE"”.
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METABOLIC AND PHARMACOKINETIC STUDIES OF BENZTROPINE AND TRIHEXYPHENIDYL
… specific methods to study pharmacokinetics for benztropine and trihexyphenidyl. Radioimmunoassay (RIA) as an alternative analytical procedure to chemical analyses was thought to provide the ultrasensitivity required for trace analysis of these drugs. The assessment of specificity in RIA and …
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Structural Determinants for Substrate and Inhibitor Recognition by the Dopamine Transporter
… of the phenyl ring substituent of cocaine, i.e. benztropine and its analogs, displayed considerably altered dopamine uptake inhibition potency as a function of the D79E mutation. These observations may suggest that the side chain of the D79 residue is important for the recognition of the aromatic …
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Anticholinergic Impact On Cognition In Schizophrenia
… between anticholinergic load as measured by benztropine equivalents and any of the MATRICS cognitive tests. In addition there were no significant differences in the mean scores of subjects in the highest anticholinergic quartile and subjects in the lowest anticholinergic quartile. These same …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… screen for novel inhibitors of viral infection. Benztropine (an inhibitor targeting B0AT1 that complexes with ACE2) and DX600 (a peptide antagonist of ACE2), were shown to exhibit antiviral properties for the first time. Additionally, the tissue expression and distribution of a recently …