Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 184 for “"BDNF"”.
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THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE
<p>Brain derived neurotrophic factor (BDNF) is a neurotrophin essential to neuron health and maintenance in both the central nervous system and periphery. It acts as a positive feedback system for the body’s motor neurons and the muscles they innervate, strengthening the synapse between them. …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
… interest is brain-derived neurotrophic factor (BDNF), a modulator of cell survival, viability, and plasticity. Cocaine has been shown to increase BDNF mRNA and protein levels in the NAc shell. In addition, intra-NAc infusions of BDNF have been demonstrated to increase cocaine intake and …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… apoptosis. Furthermore, exogenous BDNF also promotes Schwann cell survival through promoting the local release of axonal NRG1 by binding axonal trkB or p75 receptor. Consistently, increased Schwann cell death occurs both in trkB knock-out mice and after knocking-down axonal trkB in …
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HAPLOINSUFFICIENCY OF RAI1 AND ITS EFFECT ON BDNF EXPRESSION
… to SMS, we confirmed that RAI1 regulates BDNF within an intronic region. This sequence was further narrowed down by utilizing the luciferase reporter assay. This test confirmed what was previously found using ChIP-chip assay and microarray analysis of Rai1+/- mice hypothalami. Next, in …
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Investigation of Riluzole’s Synaptic Protection Mechanism Through HSF1-BDNF Axis
… We found that Riluzole could increase HSF1 and BDNF (Brain-Derived Neurotrophic Factor) expression both at transcriptional and translational levels. CA1 (Cornu Ammonia, the first region in the hip- pocampal circuit), is its main target. We also demonstrated a protective role of Riluzole on rat …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
<p>BDNF homozygous floxed mice (BDNF<sup> lox+/+</sup>) are a transgenic mouse strain used to study the neurotrophin brain-derived neurotrophic factor (BDNF) through Cre-Lox recombination when crossed with the appropriate Cre-expressing strain. BDNF<sup> lox+/+</sup> mice contain two artificially …
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Assoziationsstudien von Kandidatengenen (VMAT2, DAT, BDNF) mit Persönlichkeitsmerkmalen und psychiatrischen Erkrankungen
… DAT, Brain Derived Neurotrophic Factor BDNF) bei Persönlichkeitsmerkmalen und psychiatrischen Erkrankungen näher zu beleuchten. C. Robert Cloninger postuliert in seiner biosozialen Persönlichkeitstheorie eine genetische Grundlage von Temperamentfaktoren, die im dopaminergen, …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
<p><strong>Delineating the mechanism(s) of BDNF/TrkB mediated proliferation in Neuroblastoma</strong></p> <p> Timothy Christopher Graham, B.S.</p> <p>Supervisory Professor: Patrick Zweidler-McKay, MD/PhD</p> <p> Neuroblastoma is the most common extra-cranial solid tumor in children, arising from …
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Chronic Stress Promotes Tumor Growth Through Increased Bdnf Production and Neo-Innervation
… including brain-derived neurotrophic factor (BDNF). Neurite extension assays showed that media conditioned by ovarian cancer cell lines is capable of inducing neurite outgrowth in differentiated neuron-like PC12 cells, and NE treatment of cancer cells potentiates this effect. …
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SITUATION MOUSE ALL FLOXED UP: EXPLORING PHENOTYPIC ABNORMALITIES IN BDNF FLOXED MICE
… concerned when mice with LoxP sites flanking the BDNF gene depicted anxiety-like behaviors such as aggression, difficulty handling, and increased agitation. Though many studies have noted behavioral and phenotypic abnormalities related to large gene inserts, few have noted abnormalities with small …
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BDNF-TrkB Signaling in Efficacy of CA3-CA1 Synapses and Ketamine-Mediated Antidepressant Effects
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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A Role for BDNF-Trkb Signaling in the Modulation of Superoxide Dismutase-1 Expression
… with brain-derived neurotrophic factor (BDNF), an activator of this pathway, over shorter or ‘acute’ time periods increased SOD1 protein levels. Further analyses using qPCR, a human SOD1 promoter Lucifersase assay, and inhibitors of the proteasome and translation machinery provide …
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Role of BDNF secretion and signaling in the activity-dependent refinement of synaptic connections
… neurotrophin brain-derived neurotrophic factor (BDNF) to undergo synaptic recycling. In cortical and hippocampal slices as well as in dissociated cell cultures, neuronal activity rapidly enhances the neuronal expression and secretion of BDNF which is subsequently taken up by neurons themselves …
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NICOTINE WITHDRAWAL AND DEFICITS IN COGNITIVE FLEXIBILITY: POSSIBLE TIES TO ABERRATIONS IN FRONTOSTRIATAL BDNF SIGNALING
… and brain-derived neurotrophic factor (BDNF) modulates glutamate plasticity, we also explored the effects of nicotine withdrawal on these neurochemical substrates. Adult male C57BL/6J mice were trained in an operant task that required the animals to switch from using a spatial …
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Vliv úpolových aktivit na hladinu irisinu a BDNF v krvi u seniorů nad 65 let
… as irisin and Brain-Derived Neurotrophic Factor (BDNF). This study focuses on analyzing the effects of martial arts on the levels of these substances, synaptic plasticity, and neuroprotection in seniors over the age of 65. Additionally, it investigates the impact of this therapy on cognitive …
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Der Einfluß der Neurotrophine NGF und BDNF auf die Migration humaner eosinophiler und neutrophiler Granulozyten
… zu denen u. a. NGF (nerve growth factor) und BDNF (brain-derived neurotrophic factor) zählen, werden von zahlreichen Immunzellen gebildet, und können auf diese wiederum über spezifische Rezeptoren wirken. Außerdem wurden bereits mehrfach im Rahmen immunologischer Erkrankungen bzw. …
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Use it and boost it: cognitive and physical activities modulate cognition via BDNF-TrkB signaling
… that cognitive and physical activity increased BDNF protein, BDNF-TrkB signaling, and BDNF release in the hippocampus and striatum. Our studies show that priming the brain with cognitive and physical activities enhance hippocampus- and striatum-sensitive learning via BDNF-TrkB signaling. In …
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THE MOLECULAR AND BEHAVIORAL CHARACTERIZATION OF THE MURINE CRE – LOXP SKELETAL MUSCLE SYNTHESIZED BDNF KNOCKOUT MODEL
<p>Brain derived neurotrophic factor (BDNF) is a neurotrophin essential for supporting the growth, differentiation, and health of neurons within the central and peripheral nervous systems. BDNF is also a member of the myokine family, where muscle synthesized-BDNF (msBDNF) is thought to facilitate …
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