Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"BCRP"”.
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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates
<p>Breast Cancer Resistant Protein (BCRP) and P-glycoprotein (PGP) are membrane-bound efflux transporters that transport multiple chemical classes of compounds and act as barriers to tissue permeability, thereby regulating tissue exposure of their substrates. The role of these transporters in …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… and 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term human placenta, cultured primary trophoblast and BeWo and Jar trophoblast-like cell lines. Jar cells were found to be more similar to nondifferentiated cytotrophoblast with respect to their ABC protein …
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
… nutlin-3a on breast cancer resistance protein (BCRP), and to characterize the disposition of nutlin-3a in the mouse plasma and multiple tissues.</p> <p>Activating the p53 pathway might offer a new therapy for neuroblastoma. In the first part of the study, we assessed the effect of nutlin-3a on …
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Pharmacological modulation and manipulation of cancer drug resistance
… expression and thus, overcome P-gp, MRP1 or BCRP-mediated drug resistance, at and below pharmacologically-relevant concentrations. Two of these agents (indomethacin and 17-AAG) partially down-regulated the expression of P-gp in the A549-Taxol cell line but did not overcome P-gp-mediated …
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… (P-gp) and breast cancer resistance protein (BCRP) using intestinal organoids derived from germ free and humanized mice. Typically, transport across the epithelial cell layers occurs by active transport and passive diffusion. Using mouse models that differ in bacterial content and fluorescence …
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ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS
… of metabolic enzymes and transporters. The BCRP/ABCG2 efflux transporter was selected for the investigation of the effect of reactive anion, ONOO−, generated during OS and the product of OS, 4HNE, formed after a series of chain reactions involving ROS. Experiments conducted with Sf9 membrane …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… (Pgp) and breast cancer resistance protein (BCRP), which are known to contribute to efflux of endogenous toxins and therapeutics from the CNS. Pgp and BCRP expression and activity are a crucial determinant of drug efficacy in the CNS and have been studied using global transporter knockout …
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
… MDR1, MRP1, MRP2, MRP3 und BCRP auf die Pharmakokinetik und ausgewählte Nebenwirkungen des Zytostatikums Doxorubicin zu untersuchen. Dazu wurden die Plasmakonzentrationen von Doxorubicin und Doxorubicinol von 94 Krebspatienten durch HPLC analysiert. Die pharmakokinetischen …
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… (P-gp), Breast cancer resistance protein (BCRP) and Multidrug resistance-associated protein (MRP) in placentas from women with GDM. I have demonstrated a reduction in P-gp mRNA expression among placentas from those women treated with metformin and insulin compared to placentas from women …
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'Right to the Active City': Public Recreation and Urban Governance in Baltimore
… City Department of Recreation and Parks (BCRP) in 1940, public recreation in Baltimore has continued to be restructured in relation to changing modes of urban governance, in particular in regards to the city's network of recreation centers. More recently, the reorganization of recreation …
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Development and application of novel analytical methods for molecularly targeted cancer therapeutics
… (P-gp), Breast Cancer Resistant Protein (BCRP) and Multidrug Resistance-associated Protein (MRP-1) is an important cellular mechanism of resistance in vivo and in vitro. Using cell-line models and the developed LC-MS/MS quantification method it was established that dasatinib, an agent used …
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Characterization of Understudied Risk Factors in Chronic Kidney Disease
… OATP1A2 with limited, non-saturable efflux via BCRP. Natural-product interaction studies show luteolin inhibits and caffeic acid activates BCRP-mediated efflux at physiologically relevant intestinal concentrations, suggesting potential modulation of intestinal absorption. Next, chapter 4 tests …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… MRP2, and breast cancer resistance protein (BCRP) expression did not discriminate between sensitive and resistant cell lines. To determine the functional contribution of both MRP4 and Pgp in neuroblastoma, we used RNA interference (RNAi) to silence MRP4 and Pgp expression in NB1691. Long …
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Exploring miR-142-3p in cervical cancer: Implications for treatment response
… inhibited the cisplatin-induced upregulation of BCRP/ABCG2 in HeLa cells, suggesting a role in mitigating cisplatin-associated resistance mechanisms. miR-142-3p also reduced cell migration and suppressed EMT features, effects that were amplified in the presence of cisplatin, demonstrated by …
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Impacto de la pandemia por coronavirus (COVID-19) en exportaciones de minerales desde Perú hacia China
… (INEI), the Central Reserve Bank of Peru (BCRP) and other sources and government agencies. The methodology used is based on the use of the documentary record, this thesis compiles real data published by public bodies to be able to compare figures and review the impact of COVID-19 on the …
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Efecto de la desigualdad de ingresos en el crecimiento económico de las regiones del Perú: un análisis de datos de panel
… de fuentes oficiales como el INEI, el BCRP y el MEF. El análisis incorpora, además de la desigualdad, un conjunto de variables de control asociadas al gasto público, la inflación, el capital humano, la población y las exportaciones. Los resultados obtenidos evidencian que la desigualdad …
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La clave detrás del éxito del "nuevo dólar" latinoamericano: un análisis sobre la efectividad de la flotación sucia en el Perú
… cambiaria del Banco Central de Reserva del Perú (BCRP) durante el período 2004 – 2024. La teoría del canal de coordinación nos indica que los participantes del mercado cambiario interpretan las intervenciones cambiarias como indicadores sobre la postura económica del banco central, bajo la …
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ROLES OF SULFOTRANSFERASE ENZYMES IN TRANS-PLACENTAL DISPOSITION
… The breast cancer resistance protein (BCRP) played a minor role in the elimination of these two sulfate conjugates across the apical membrane.
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Relación de la inversión extranjera directa y la desigualdad de los ingresos en los países de la Alianza Pacífico (1998-2019)
… de Colombia (BRC), Banco Central de Perú (BCRP), Banco Central de Chile (BCCH), Instituto Nacional de Estadística y Geografía (INEGI). Los resultados muestran que la inversión extranjera directa total tiene un efecto positivo en la desigualdad de ingresos y la magnitud de su efecto ha sido …
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Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
… (P-gp) and breast cancer resistance protein (BCRP) are the two major efflux proteins that restrict the entry of xenobiotics across BBB. Overexpression of these efflux pumps in brain tumors at the BBB further compromises brain penetration of anti-tumor agents. The broad objective of this …
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