Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"BCR signaling"”.
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B Cell Receptor Signalng in Germinal Centers
… antigen capture function of the B cell receptor (BCR). However, the BCR can also function as a signaling entity, and it is not well understood how signaling by the B cell receptor contributes to selection. The critical barriers to addressing this question have been a lack of specific BCR signaling …
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The Role of Pag1 In The Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma
… is characterized by chronic antigen-driven signaling by the B-cell receptor (BCR), indicating an escape from immunologic tolerance mechanisms that normally regulate self-reactive B cells. While recent therapies have focused on inhibiting the kinases that propagate BCR signaling with mixed …
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The Dual Role of OCA-B in B Cell Development and Signaling
… expression, germinal center formation and BCR dependent proliferation. These defects contribute to the severely impaired antigen-dependent immune responses of Oca-b-/- mice. The later identification of a membrane-bound, myristoylated form of OCA-B suggested additional, potentially unique …
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Exploiting biological pathways to infer temporal gene interaction models
… We focus instead on the B cell receptor (BCR) signaling pathway, which narrows the inference problem and provides a clinical application, as B cell chronic lymphocytic leukemia (B-CLL) is believed to be related to BCR response. In this work, we infer population-dependent gene networks of …
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Mechanism for Pre-B Cell Loss in Mutant Ali/Ali Rabbits
<p>Pre-B cell receptor (pre-BCR) signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional μ-chains undergo selective expansion. My dissertation work used a rabbit model system to study how VH structure affects the early stages of B cell development in …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… of self-antigens by the B cell receptor (BCR), development of autoimmune memory and beneficial therapeutic approaches by targeting B cells highlight the pathogenic role of B cells in development and maintenance of autoimmunity [2-10]. Genotyping and genome wide association studies (GWAS) …
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… have defects in inhibitors of B cell receptor (BCR) signaling or plasma cell differentiation. Autoantibodies against a wide range of self antigens contribute to the pathogenesis of SLE and are used to diagnose SLE, determine prognosis, and predict specific disease manifestations. Autoantibodies …
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Actions of Pi3K-Delta Inhibitor, Idelalisib, and Its Combination With Bendamustine In Chronic Lymphocytic Leukemia
… dysregulated in many cancers and aberrant PI3K signaling is associated with oncogene mutations and disease progression in solid tumors and in hematologic malignancies.</p> <p>Chronic lymphocytic leukemia (CLL) is driven by B-cell receptor (BCR) signaling that promotes B-cell proliferation and …
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
… mutated IgVH genes on the B-cell receptor (BCR) have a good prognosis, whereas patients who express unmutated IgVH genes have a poor prognosis. However IgVH gene mutational status is an expensive and time consuming test and would not be practical for routine clinical practice. If the B-cell …
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Targeting Epigenetic Regulators For The Treatment of Diffuse Large B-Cell Lymphoma
… cells, we found that B-Cell Receptor (BCR) signaling was enhanced after EZH2 inhibitor treatment, and associated with an activated B-cell phenotype. Genetic manipulation of BCR, CD19 and CD79A greatly increased sensitivity to the EZH2 inhibitor EPZ-6438. Combination therapy with SYK, …
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… for its involvement in B-cell receptor (BCR) signaling but our previous data have demonstrated that SYK is also involved in tau yperphosphorylation and A-beta production, therefore suggesting that SYK could contribute to the formation of AD pathological lesions.<br></br><br></br>The goals …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… (Btk), which is critical to B cell receptor (BCR) signaling, mediates BCR hypersensitivity and autoantibody production in lyn-/- mice. B cell hyperresponsiveness is not, however, sufficient for the autoimmune phenotype; additional Btk-dependent events are required. Btk also contributes to …
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
… these assays show a decrease in response to BCR signaling in BAFF-treated cultures compared to untreated controls. Additional studies with sorted populations of cells indicate that these An1 cells are emerging mainly from the mature and the T2 populations. Survival studies using Annexin V as …
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The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins
The B cell antigen receptor (BCR) is composed of the membrane-bound immunoglobulin (mIg) <br>and the Ig-alpha/Ig-beta heterodimer and plays a central role in development, survival, and activation <br>of B lymphocytes. During B cell development, the BCR seems to be able to generate signals in <br>an …
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
… kinases in the EBV lytic program. To this end, signaling pathways mediating Epstein-Barr virus (EBV) reactivation by antigen-bound B-cell receptor (BCR) were analyzed using a panel of 80 protein kinase inhibitors. Broad range protein kinase inhibitors Staurosporin, K252A, and PKC-412 …
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Functional Drivers of Therapeutic Response in Diffuse Large B Cell Lymphoma
… death and a marked reduction in B cell receptor (BCR) signaling effectors. Further work in BCR signal transduction places FAK near the intracellular interface with the BCR, as the first effector molecules in the pathway have vastly reduced activity with FAK inhibition. Mouse models of Fak knockout …