Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"BCNU"”.
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Identifying a transcriptional signature for cell sensitivity to the cancer chemotherapy agent, BCNU
… agent, 1,3-bis-(2-chloroethyl)- 1 -nitrosourea (BCNU or carmustine). Cell lines with extreme sensitivity or resistance to BCNU were identified from a set of twenty four genetically diverse human lymphoblastoid cell lines using a high-throughput method that was developed as part of this thesis. …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
… are highly variable in their sensitivity to BCNU. We therefore set out to determine mechanisms underlying this difference in phenotypic responses. Using gene expression analysis methods, we determined that the transcription factor NF-Y plays a key role in the differential response among cell …
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Computational analysis of genomic data provides insight into cell sensitivity to BCNU-Induced DNA damage
… are highly variable in their sensitivity to BCNU. We therefore set out to determine mechanisms underlying this difference in phenotypic responses. Using gene expression analysis methods, we determined that the transcription factor NF-Y plays a key role in the differential response among cell …
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
… such as 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and chlorozotocin (CLZ) can cure almost 100% of C57BL/6 mice bearing syngeneic LSA tumor. In contrast, similiar or higher doses of streptozotocin (STZ) completely failed to cure LSA-bearing mice. Further studies revealed that the efficacy of …
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Characterization of electrospun DLPLGA nanofibers for a drug delivery system for intracranial tumors and AVMs
… 1 ,3-bis (2-chloroethyl)- 1 -nitrosourea (BCNU) was then codissolved with the DLPLGA nanofibers to form a homogenous solution, electrospun, and analyzed for drug characterization. The SEM analysis showed that fiber diameter is not a function of drug presence. The IGA graphs showed little …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… (GR) with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Here too, interference in tumor cell GSH metabolism enhanced cytolysis by a flux of H<sub>2</sub>O<sub>2</sub>. In contrast, inhibition of catalase with aminotriazole had little effect. This theme was extended into another arena of GSH …
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Mechanical characterization and in vivo operation of an implantable drug delivery MEMS device
… chemotherapeutic agent (carmustine, or BCNU) from the device. However, systematic characterization of the mechanical and electrochemical behavior of gold membranes on the drug delivery device was necessary in order to achieve more reliable device performance and to demonstrate efficacy …
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Low Reactive Oxygen Species and High Glycolysis In Glioblastoma Stem Cells:Mechanisms and Therapeutic Implications
… inhibitor 3-BrOP and a chemotherapeutic agent BCNU depleted cellular ATP and inhibited the repair of BCNU-induced DNA damage, achieving strikingly synergistic killing effects in drug resistant GSCs.</p> <p>This study uncovers the metabolic properties of glioblastoma stem cells and suggests that …
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Charakterisierung eines parvoviralen Hybridvektors hinsichtlich der Transduktion und präferentiellen Expression in transformierten Zellen
… wie Cisplatin, Mitomycin und Carmustine (BCNU) gesteigert werden. Somit verhält sich der Hybridvektor TRH1-GFP wie ein reiner AAV-2 Vektor. Eine Stimulierung der Transduktion mit AAV-2 Vektoren durch Chemotherapeutika oder Gamma-Bestrahlung bietet die Möglichkeit einer …
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Use of the Immune System to Investigate the Toxicity Induced by Environmental Pollutants in Fish, Amphibian, and Mammalian Species
… with 1,3-Bis (chloroethyl)-1-nitrosourea (BCNU). Immunotoxicity of the tilapian immune system was detectable using mitogen-induced proliferation assay and cell-mediated toxicity assay. Fish from various streams of the Roanoke River were tested for immunotoxicity and parasitic infection. …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… such as TMZ, Lomustine (CCNU) and Carmustine (BCNU), showed synergistic cytotoxicity and sensitized the GBM cell lines to first line drugs tested in this study. This study further explored the possible mechanisms of action of DMSA+Cu such as generation of reactive oxygen species (ROS), …
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Local exposure and efficacy of a reservoir-based drug delivery device
… conventional treatment. Implantable Gliadel® BCNU wafers were approved by the FDA, but patients still experienced side effects such as edema, and median survival time was improved only by 2 months. Convection-enhanced delivery (the infusion of chemotherapeutics via catheters) may achieve …