Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"BCLXL"”.
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Nachweis des apoptoseinduzierenden Faktors in Lewis-Lung-Karzinom Zellüberstand nach Inkubation von Kulturmakrophagen der C57/BL6 Maus
… Methoden der Anteil an bax bzw. bclxL positiver Zellen bestimmt. Das Apoptosemaximum ergab sich hierbei am 11. Kulturtag, wobei sowohl bax, und bcl-xL, jeweils signifikant erhöhte, bzw. erniedrigte Werte nach Inkubation der Makrophagen mit dem Tumorzellüberstand zeigten. Zum …
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Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
… expression of p21. VPA reduces levels of BclxL, induces cleavage of Bid, translocation of Bax to mitochondria, release of cytochrome c into cytosol and phosphorylation of Erk and H2AX. Transcriptomic analyses by microarrays and quantitative RT-PCR have underscored a series of genes …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… and HPAECs is mediated through the BMPRII-ALK1-BclxL axis. Finally, the siRNA screen targeting approximately 1000 genes has identified novel proteins including PPP1CA, IGF-1R, MPP1, MCM5 and SRC each capable of modulating the BMPRII signalling. Taken together, this study for the very first time …
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… upregulated the p53-dependent genes Bax, BclxL, and MDM2 at least 2-fold. p53 was phosphorylated at Ser 15 in mouse hearts 1 h following doxorubicin injection, and p38 and ERK1/2 MAPKs mediated the phosphorylation of p53. In addition, caspases-3 and -9 were activated 24 h after doxorubicin …
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Resistance to Apoptosis in Smooth Muscle Cells and Stent-Induced Stenosis in Coronary and Peripheral Arteries
… aortic VSMCs while expression of PKC a, PKC 8, bclxL and bcl-2 did not differ between the two cell lines. The findings of these investigations demonstrated that (1) in comparison to internal iliac arteries, coronary arteries have a higher tendency towards intimal hyperplasia after stenting and …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
<p>Despite major advancements in the management of chronic lymphocytic leukemia (CLL), drug resistance remains a major challenge. CLL resistant to venetoclax (VEN) have limited available therapeutic options, especially when the leukemic cells have dysfunctional p53 and have relapsed on Bruton’s …