Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"BCL2L1"”.
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Single Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms
… At relapse, we confirmed the upregulated BCL2L1 in the predominant erythroid compartment in patient who had displayed an erythroid shift. Furthermore, we confirmed the upregulated MCL1 in the monocytic compartments of two patients with monocytic shifts. In one of these patients, scRNAseq …
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Role of microRNA 214 in cyclic stretch induced aortic valve pathogenesis
… targets (ATF4) and downstream genes (CHOP and BCL2L1) in porcine AVs ex vivo. Also, the effect of miR-214 overexpression on porcine AV calcification is evaluated. This would give a better understanding on the potential therapeutic role of miR-214 in CAVD.
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
… of two anti-apoptotic genes BCL2A1 and BCL2L1 increased under MIXL1 over-expression conditions and decreased under conditions of MIXL1 knockdown by targeted shRNA in U937 cells. In summary, my studies identify c-REL to be a novel mediator of MIXL1-induced survival signals in leukemia.</p>
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Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… analyses reveal that pro-apoptotic genes (BCL2L11/BIM, BOK and AIFM2) are androgen-induced, whereas pro-survival genes (BCL2L1/BCL-XL and MCL1) are androgen-repressed. Hence, we propose that the net effect of these AR-mediated expression changes shifts the balance of BCL2-family proteins in …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… <em>BCL2 </em>and gained BCL-XL/<em>BCL2L1</em> and BIM/<em>BCL2L11 </em>at relapse, which was a phenomenon affecting all clusters, including the most dominant. Moreover, a minor cluster was recurrently expanded in <em>TP53</em>-mutated relapsed CLL with low levels of <em>BCL2</em> …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… the expression of the anti-apoptotic protein, BCL2L1 possibly by reducing the activation of the NFkB pathway. Ovarian tumors from 4 year old hens appeared to over-express estrogen receptor along the glandular area of the tumor but not the stroma. In the 3 year old pre-neoplastic hen ovaries, …