Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"BCL2A1"”.
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Development of Models for the Action of Novel Anti-apoptotic Proteins using Gene Regulation, Pathway Analysis and Protein Structure Prediction
… analysis.<br/>Protein and gene data sets for BCL2A1 and TMBIM6 were provided by Morvus Technology. Further protein sequences were retrieved from public databases for comparison using multiple sequence analysis. Nine new variants of BCL2A1 were identified. Homology modelling was used to predict …
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Detection of periodontal bacteria in atherosclerotic plaque
… adhesion molecule ICAM-1. Anti-apoptotic gene BCL2A1 showed the greatest increase in mRNA compared to all tested genes. Expression of the same panel of genes direct in atherosclerotic plaque tissue resulted in similar expression patterns.
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The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
… apoptosis and B cell activation (Bcl2A1, LTA, CD69) which were<br/>confirmed using RT-Q-PCR.<br/><br/>This novel combination elicits the induction of apoptosis in vitro, potentially<br/>through regulation of Bcl-2 family proteins and should be tested in a phase<br/>I/II clinical …
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
… of c-REL, expression of two anti-apoptotic genes BCL2A1 and BCL2L1 increased under MIXL1 over-expression conditions and decreased under conditions of MIXL1 knockdown by targeted shRNA in U937 cells. In summary, my studies identify c-REL to be a novel mediator of MIXL1-induced survival signals in …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… along with its anti-apoptotic targets <em>BCL2A1</em>/BFL1 and <em>MCL1</em>. Other 2 minor clusters were gained at relapse by two independent <em>TP53</em>-mutated CLL samples, with high co-expression of <em>BCL2</em>, <em>MCL1,</em> and the pro-apoptotic binding partner of MCL1, …
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Identification of Subclass-Specific Biomarkers by Developing an Integrated Database of Breast Cancer
… metastasis related genes including MMP12 and BCL2A1, CXCL5 are observed. On the other hand, FOS, which known as oncogenes, and TFF2, which is known to induce endocervicitis that closely associated to breast disease, are underexpreseed. To check the classification accuracy of these genes, we …