Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"BCL2"”.
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… reflecting the residual activity of pro-survival BCL2 proteins. In this thesis, we determined that melanoma cells had a high MCL1:BCL-XL ratio, and as a result were biased towards MCL1 due to low expression of BCL-XL. Consequently, melanoma cells were uniquely dependent on MCL1 to restrain the …
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"Ανάλυση έκφρασης μεταγράφων γονιδίων της οικογένειας BCL2 σε ανθρώπινα λευχαιμικά κύτταρα"
Η Οξεία Μυελογενής Λευχαιμία (ΟΜΛ) αποτελεί μια επιθετική αιματολογική κακοήθεια που χαρακτηρίζεται από διαταραχή του πολλαπλασιασμού και της διαφοροποίησης των αιμοποιητικών βλαστικών κυττάρων, οδηγώντας σε συσσώρευση ανώριμων μυελοβλαστών στον μυελό των οστών και στο περιφερικό αίμα και τελικά σε …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… VEN-relapsed CLL exhibits altered dependence on BCL2 family members, which can be exploited for therapeutic benefit. I profiled 28 CLL samples collected from 15 patients either at baseline or at relapse following VEN treatment, which was administered in combination with a BTKi or sequentially as …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
<p>Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease involving rapid degeneration of motor neurons in the spinal cord and retraction of their axonal projections to the neuromuscular junctions. Several known mutations linked to some familial cases of ALS have been linked …
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Molecular characterisation of Diffuse large B-cell lymphomas (DLBCL) diagnosed at Groote Schuur Hospital (GSH)
… genetic alterations in oncogenes such as MYC, BCL2 and BCL6 as well as viral oncogenes, contribute to its development and progression. In the World Health Organisation (WHO) classification of haematolymphoid tumours, the classification of DLBCL requires testing for MYC, BCL2 and BCL6 genetic …
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ZFP36 proteins and mRNA targets in B cell malignancies
… that have important roles in B cell biology, BCL2 and CD38 mRNAs. BCL2 is an anti-apoptotic protein with key roles in cell survival and carcinogenesis; CD38 is a membrane protein differentially expressed in B cells and with a prognostic value in B chronic lymphocytic leukaemia (B-CLL), …
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Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
… the anti-apoptotic mRNA B Cell Lymphoma 2 (BCL2) as a conserved miR-21 target. Consistent with this, miR-21 overexpression decreased BCL2 transcript and protein expression, while miR-21 inhibition increased BCL2 protein levels and reduced cleaved caspase-3 levels following …
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Molecular Mechanisms Regulating Neonatal Oocyte Survival and Primordial Follicle Formation in the Mouse Ovary
… that two anti-apoptotic regulators from the BCL2 family of proteins, BCL2 and MCL1, may be responsible for regulating neonatal oocyte survival. To elucidate the effects of BCL2 in the neonatal ovary, we examined ovaries of both <em>Bcl2</em> overexpressing and knockout transgenic mice. When …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… fluorescent in situ hybridisation analysis for *BCL2* and *BCL6* translocation. The final diagnosis included 40 cases of EMZL (9 *BCL6* translocation positive), 22 cases of FL (5 *BCL2* translocation positive, 11 *BCL6* translocation positive, 1 both *BCL2/BCL6* translocation positive) and 36 …
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Mechanism of methoxychlor toxicity in mouse ovarian antral follicles
… examining the effects of MXC on steroid levels, Bcl2 factors and caspase activity, and by determining if MXC exerts toxicity through an AHR pathway. Since MXC is known to target antral follicles, the major producer of sex steroids in the ovary, the present study first tested the hypothesis that …
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Characterizing ASCL1-Dependent Neuroendocrine Non-Small Cell Lung Cancers
… transcription of the anti-apoptotic regulator BCL2. Inhibition of BCL2 in vitro and in vivo led to induction of apoptosis and tumor xenograft regression suggesting that BCL2 is a potential therapeutic target in ASCL1-dependent NE-NSCLCs. Analysis of the upstream regulation of ASCL1 showed that …
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MECHANISMS OF NEUROPROTECTION IN SCN2.2 CELLS
… levels in either cell type with Glu treatment. Bcl2 levels remained unchanged in the Glu-treated GT1-7 cells. Although there was no change in the Bcl2 mRNA levels in the SCN2.2 cells, Bcl2 protein was significantly increased with Glu treatment, thus suggesting a post-translational mechanism of …
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Delineating the Steps of BAX Pore Activation
The BCL2 protein family is the primary gatekeeper of mitochondrial apoptosis and governs integrity of the organelles' outer membranes. Permeabilization of mitochondrial outer membranes permits egress of cytochrome c and other apoptogenic factors, resulting in apoptosome formation, caspase …
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DRE-1/FBXO11, a Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
… induces apoptosis. In addition, FBXO11 binds to BCL2 in lymphoma cell lines and induces the degradation of BCL2, and expression of BCL2 rescues the toxicity of FBXO11. Taken together, our results establish dre-1/FBXO11 as a regulator of apoptosis in C. elegans and human lymphoma, and suggest a …
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Single Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms
… we profiled the expression levels of various BCL2 family proteins through single-cell RNA sequencing. We studied four patients who had displayed the phenotypic shifts by DAb-seq analysis. At relapse, we confirmed the upregulated BCL2L1 in the predominant erythroid compartment in patient who …
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Establishing the feasibility of using ctDNA for molecular profiling in DLBCL
… classification. Finally, I demonstrated that BCL2 somatic hypermutation status is highly predictive of BCL2 structural variant status. This could be used instead of fluorescent in situ hybridisation to call BCL2 structural variants in DLBCL. In the experience of the DIRECT trial, genotyping …
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Profilo molecolare dei linfomi post-trapianto
… loss of the tissue core. FISH analysis detected BCL2 gene amplification and MYC rearrangement. EBV was identified in 32 cases (64%) performing immunohistochemistry (LMP-1) and in situ hybridization (EBER). Clinical data and follow-up were available in all cases of malignant lymphomas but one. …
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