Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"BCL-XL"”.
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Role of BCL-XL in cell death after spinal cord injury
… in protein levels of the anti-apoptotic protein Bcl-xL. In this dissertation, I assessed the role that Bcl-xL subcellular re-routing and post-translational phosphorylation play in SCI-induced Bcl-xL decreases, and evaluated the therapeutic potential of Bcl-xL-administration after SCI. …
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Role of Bcl-xL in Doxorubicin-Induced Cell Death: Apoptosis and Mitotic Cell Death
Bcl-xL overexpressed in various human cancer cells contributes to resistance against various chemotherapeutic agents. In this study, we compared the role of Bcl-xL in high dose (HD) doxorubicin-induced apoptosis and low dose (LD) doxorubicin-induced mitotic cell death. In the first part of this …
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Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
… und anti-apoptotischen Fusionsprotein TAT-Bcl-xL transduziert. Ziel dieser Dissertationsarbeit war die Untersuchung von Überleben, Migration und Differenzierung transplantierter, transduzierter GFP+-NPC im Vergleich zu unbehandelten/nativen NPC nach Induktion einer transienten fokalen …
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The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1
… cells. Crucially, I found that the antiapoptotic Bcl-xL protein was upregulated in MPNST cells and the increased Bcl-xL expression caused an increase in an MPNST cell’s resistance to anticancer drugs. These results suggest that the alteration of the Bcl-xL expression level by somatic expression …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… VEN-relapsed CLL exhibits altered dependence on BCL2 family members, which can be exploited for therapeutic benefit. I profiled 28 CLL samples collected from 15 patients either at baseline or at relapse following VEN treatment, which was administered in combination with a BTKi or sequentially as …
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Insights into p53-Dependent Apoptotic Signaling and Cell Fate vis-a-vis Functional Cooperation among BCL-xL, Cytoplasmic p53, and PUMA
… that binds and inhibits the anti‑apoptotic BCL‑2 repertoire, including BCL‑xL. Structural investigations of PUMA and the BCL‑xL×PUMA BH3 domain complex by X‑ray crystallography and nuclear magnetic resonance (NMR) spectroscopy reveal a novel, PUMA‑induced, domain‑swapped dimerization of …
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세포자멸사 촉진분자를 이용한 암 치료용 단백질치료제의 개발
… inductcing stimulus - 6 C. Construct - 7 D. 돌연변이 Bcl-xL의 과발현을 위한 construc 구축 - 8 E. Transfection - 9 F. Western blot analysis - 10 G. Fluorescence activated cell sorter(FACS) analysis - 11 H. co-Immunoprecipitation analysis - 11 I. Confocal microscopy - 13 Ⅲ. 결 과 - 14 A. 돌연변이 Bcl-xL(5A) 단백질의 세포자멸사 …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… reflecting the residual activity of pro-survival BCL2 proteins. In this thesis, we determined that melanoma cells had a high MCL1:BCL-XL ratio, and as a result were biased towards MCL1 due to low expression of BCL-XL. Consequently, melanoma cells were uniquely dependent on MCL1 to restrain the …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
… CML blast crisis cells with differential BCL-XL/BCL-2 expressions. Additionally, an artificial CML cell model with heterogenic BCL-XL/BCL-2 expression was established to assess the correlation between differential survival factor expression patterns and cell sensitivity to Imatinib and …
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BIOPHYSICAL STUDIES OF THE MECHANISM OF CERAMIDE CHANNEL DESTABLIZATION BY BCL-XL IN APOPTOSIS AND THE USE OF RECTIFICATION TO PROBE THE STRUCTURE AND DYNAMICS OF A NOVEL ESCHERICHIA COLI CHANNEL
… the apoptotic process. An antiapoptotic protein, Bcl-xL, regulates the apoptotic process and inhibits the formation of ceramide channels. However, there is no precedent to indicate how a protein regulates a lipid channel. We investigated the mechanism of this regulation and identified the …
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pH-Triggered Membrane Insertion of Proteins
… (T domain) and the anti-apoptotic regulator Bcl-xL. We addressed the following specific questions: (1) Do structurally similar T domain and Bcl-xL share common mechanisms of membrane insertion? (2) What is the role of titratable histidine residues on the late stages of transmembrane insertion …
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Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation
… cells are shown to constitutively overexpress Bcl-XL protein when compared to the IL-6 independent, Stat3 negative, human myeloma cell line 8226. Comparison of the two cell lines reveals that U266 cells are inherently resistant to Fas-mediated apoptosis and cytotoxic drugs when compared to 8226 …
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ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE
… negative form of Fas (dnFas) or over-expressing Bcl-XL had reduced caspase-3 activation following infection with M51R VSV indicating that both the death receptor and mitochondrial pathways are important for M51R VSV induced apoptosis. Direct activation of Fas in Bcl-XL over-expressing cells …
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RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE
… overexpression of the antiapoptotic protein Bcl-xL plays a role in resistance of prostate cancer cells to VSV. By overexpressing Bcl-xL in VSV-sensitive LNCaP cells and silencing Bcl-xL expression in VSV-resistant PC3 cells, I was able to demonstrate that the level of Bcl-xL expression is …
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p38 MAPK Signalling in Endothelial Apoptosis
… cell death, p38 mediates phosphorylation of Bcl-xL, which is followed by Bcl-xL degradation in the proteasomes. Furthermore, we observed that p38 signalling inhibits the MEK/ERK survival pathway and the phosphorylation of its downstream target Bad, which ocurris through an increased …
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Biochemische und molekularbiologische Charakterisierung von Spike, einem neuen BH3-Domänen Protein
… regulating protein complex, consisting of Bap31, Bcl-2, Bcl-XL and an ER-specific isoform of caspase-8: pro-caspase 8L (Breckenridge et al. 2002). Although no direct interaction with anti-apoptotic members of the Bcl2-family could be observed, the importance of the BH3-like sequence for the …
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Vesicular stomatitis virus induced apoptosis occurs by a mechanism involving the activation of pro-apoptotic Bcl-2 proteins Bak and Bid and the inactivation of anti-apoptotic Bcl-2 proteins Bcl-XL and Mcl-1
… of my thesis I address the question of what role Bcl-2 family proteins play in apoptosis induced by vesicular stomatitis virus (VSV) with wild-type (wt) M protein (rWT virus). My results demonstrate that of the two major proapoptotic multidomain proteins Bak and Bax, Bak is more important for the …
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Counterattack: ein Prinzip der Metastasierung maligner Tumoren?
… <br>Verfahren. Als Apoptosemarker dienten bax, bcl-2 und bcl-XL. <br>Die Untersuchungsergebnisse zeigten bei allen Malignomen, dass ihre TZÜ eine Apoptoseinduktion <br>auslösten, wobei sich die Aussagen der einzelnen Apoptosemarker untereinander deutlich <br>unterschieden. <br>Bei LL und EL4 …
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NMR structural and functional studies of the mithochondrial outer membrane protein VDAC by Thomas J. Malia.
… during development and for tissue maintenance. Bcl-2 family proteins are central regulators of apoptosis and many of their primary roles are carried out in the outer mitochondrial membrane. Anti-apoptotic Bcl-xL has been found previously to interact with VDAC, an outer mitochondrial membrane …
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