Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"BCL-2 family"”.
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The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases
The development of the immune system is a highly dynamic process, characterized by quickly and frequently changing cell types and numbers. The orchestration of cell growth and proliferation and also of cell death is a necessarily complex process, taking cues from a wide variety of sources. The …
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Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… 51). The process of apoptosis is mediated by the Bcl-2 protein family (2, 46, 226). The purpose of this research was to define the molecular mechanisms of Stx-2 and Bcl-2 protein family interactions. These studies examined the binding of Stx-2 to select Bcl-2 family proteins, and outlined the …
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Bcl-2 Function in Drosophila
Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a step necessary for the initiation of the caspase cascade. Worms and flies do …
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Autophagy in Metabolism, Cell Death, and Leukemogenesis
… can also lead to apoptosis mediated through Bcl-2 family proteins, and Bcl-2 has been reported to interfere with autophagy, potentially disrupting a key nutrient source just as glucose uptake becomes limiting. Since autophagy may support survival or lead to death depending on context, the …
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Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis
… of activation and delay of apoptosis, however, bcl-2 family proteins have been implicated in the control of neutrophil apoptosis. This study helps to define the role of several bcl-2 family proteins (both pro- and anti-apoptotic) by examining the differential expression of these proteins upon …
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Rapid turnover of McL-1 couples translation to cell survival and apoptosis
… by inhibition of caspases or overexpression of Bcl-2 family proteins Bak and Bax were activated concomitantly with detection of cell death following cycloheximide treatment. Moreover, inhibition of the proteasome abrogated Bak/Bax activation, indicating that the loss of short-lived protein(s) …
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THE EFFECTS OF ACIDOSIS ON SURVIVAL PATHWAYS IN LYMPHOID MALIGNANCIES
… of several apoptosis-governing members of the Bcl-2 family. More specifically, we find that acidosis signals the elevation of anti-apoptotic Bcl-2 and Bcl-xL, while also reducing levels of pro-apoptotic PUMA and Bim. Further mechanistic studies revealed that the induction of anti-apoptotic …
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
Human Noxa, a BH3-only member of the Bcl-2 family of apoptosis regulators, was shown to have both pro-apoptotic and pro-survival functions in human hematological malignancies. Noxa protein is not expressed in unstimulated or naïve human T cells but is induced in CD8+ T cells upon receptor …
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Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
… critical for the functional roles played by each family member, which can be overlapping or distinct. The two peptide recognition domain families discussed in this work, Bcl-2 and TRAF proteins, have roles in cellular processes including apoptosis, inflammation, and immunity. Aberrant function of …
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Žūties ir išgyvenimo signalinių mechanizmų tyrimai suaugusio organizmo raumens kamieninių ląstelių diferenciacijos metu /
… a potential to regulate pro- and antiapoptotic Bcl-2 family protein level in this cells. We have also shown the ability of JNK to regulate pro-survival Akt kinase phosphorylation level in differentiated cells. In conclusion, our results show that modulation of Akt and MAP kinases activity in …
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Anti-apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration
<p>MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of multiple cell lineages, is also among the most highly amplified genes in cancer. Although MCL-1 is known to oppose cell death, precisely how it functions to promote survival of normal and malignant cells is poorly …
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The regulation of programmed and pathological cell death in C. elegans
… inhibition by the cell-death regulator CED-9, a Bcl-2 family member. The binding of EGL- 1 to CED-9 releases the Apaf- 1-like adaptor protein CED-4 from CED-9, so that CED-4 can activate the caspase CED-3, a protease that is the effector of programmed cell death. In this thesis, I describe three …
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From disorder to order: the importance of context in protein folding and binding mechanisms
… Next we employed protein members of the BCL-2 family – involved in controlling the cell death mechanism – to understand what encodes a coupled folding and binding reaction. Although displaying a variety of conformations, some IDPs can fold upon binding to a partner protein. Promiscuous …
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Taspase1 is a Non-oncogene Mediator of Tumorigenesis and Maintenance
… p27 and destabilizes the anti-apoptotic BCL-2 family member MCL-1. Decreased levels of MCL-1 in glioblastoma and melanoma due to Taspase1 loss sensitizes these cells to a variety of apoptotic stimuli, including anoikis, DNA damaging agents etoposide and doxorubicin, and to a targeted …
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Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… demonstrate that PUMA, a BH3-only member of the Bcl-2 family is essential for ER stress-induced cell death. PUMA is known to be a key transcriptional target of p53, however we have found that ER stress triggers PUMA induction and cell death through a p53-independent mechanism involving instead …
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NMR structural and functional studies of the mithochondrial outer membrane protein VDAC by Thomas J. Malia.
… during development and for tissue maintenance. Bcl-2 family proteins are central regulators of apoptosis and many of their primary roles are carried out in the outer mitochondrial membrane. Anti-apoptotic Bcl-xL has been found previously to interact with VDAC, an outer mitochondrial membrane …
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Modeling the flexibility of alpha helices in protein interfaces : structure based design and prediction of helix-mediated protein-protein interactions
… peptide inhibitors of the apoptosis-related Bcl-2 family member, Bcl-xL, and a modification of Crick Parameterization is used to predict the binding orientation of dimeric coiled coils with greater than 80% accuracy. Finally, this study addresses the increase in computational time required by …
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The Role of MCL-1 in the Heart: Gateway from Life to Death
<p>MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we have demonstrated that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy preceded by loss of …
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The role of cardiolipin in the regulation of mitochondria-dependent apoptosis
… cytosol is tightly regulated by proteins of the Bcl-2 family and results in the activation of the caspase cascade, leading to cell death. This event is considered as a point of no return in the apoptotic pathway and is often inhibited in cancer. Cardiolipin (CL) is a mitochondria-specific …
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